Non-PVC film soft bag large infusion has simple and easy to control production process, no secondary pollution during use, good compatibility of membrane and drug, high safety, long shelf life and light weight, convenient for trafficking and use, etc. The market is widely recognized. According to statistics, the output in 2009 has reached 1.66 billion bags, accounting for 20.73%. In 2010, the glass bottle, plastic bottle and soft bag accounted for a 4:3:3 pattern. However, due to the complex production process, difficult quality control, high energy consumption and secondary pollution in the process of plastic bottle infusion, It will become a transitional product type. The National Development and Reform Commission issued an industrial guidance opinion in 2007, which has included the two-step plastic bottle infusion production as a restricted category. Therefore, in the near future, China's large infusion market will probably be fully synchronized with international advanced developed countries and regions. The market pattern of 70%~80% soft bags and 20%~30% glass bottles is gradually formed. This brings great opportunities for the development of large infusions of soft bags. At the same time, with the implementation of the new rural cooperative medical system and the urban basic medical security system, the amount of basic infusion will probably increase exponentially, but there will be certain restrictions on the price of the drug. For large infusion pharmaceutical companies, challenges and opportunities coexist. Here's how to do a large-scale infusion of soft bags on a large scale. I propose some suggestions and solutions from the perspective of equipment technology.
First, the main factors affecting large-scale low-cost production of non-PVC film soft bag large infusions are:
1. The reliability and stability of the main equipment such as bag making and potting equipment, the pass rate of bag making and potting, the economics of use and the bag leakage rate (ie microleakage occurs before the lamp is used in the hospital for 15 days after the lamp is inspected). And the deterioration of the drug caused by leakage and the appearance of mildew, etc.).
2, the price of the main packaging materials (mouth, cover, film), largely determines the cost of non-PVC film soft bag large infusion, and directly determines the market price, affecting market competitiveness.
3. How to improve the efficiency and production capacity of the production line and reduce the consumption of manpower, water, electricity and gas.
Due to the fierce price competition of the basic infusion, the profit of each bag of infusion products will be transferred from the current few yuan, a few angles to a few points, a few cents. Therefore, in the preparation of non-PVC film soft bag large infusion project, we must seriously consider the above factors, and lay a good foundation for future large-scale low-cost production.
Second, the solution <br> <br> non-PVC film soft bag infusion production processes
As can be seen from the above table, the packaging cost of the large infusion of the self-made mouth tube, cap, and membrane soft bag can be basically equal to or even lower than that of the glass bottle.
Annual production of 70 million bags of non-PVC film soft bag large infusion project main equipment investment table unit: 10,000 yuan
The entire project can be fully recovered within one year after the project is completed.
First, the main factors affecting large-scale low-cost production of non-PVC film soft bag large infusions are:
1. The reliability and stability of the main equipment such as bag making and potting equipment, the pass rate of bag making and potting, the economics of use and the bag leakage rate (ie microleakage occurs before the lamp is used in the hospital for 15 days after the lamp is inspected). And the deterioration of the drug caused by leakage and the appearance of mildew, etc.).
2, the price of the main packaging materials (mouth, cover, film), largely determines the cost of non-PVC film soft bag large infusion, and directly determines the market price, affecting market competitiveness.
3. How to improve the efficiency and production capacity of the production line and reduce the consumption of manpower, water, electricity and gas.
Due to the fierce price competition of the basic infusion, the profit of each bag of infusion products will be transferred from the current few yuan, a few angles to a few points, a few cents. Therefore, in the preparation of non-PVC film soft bag large infusion project, we must seriously consider the above factors, and lay a good foundation for future large-scale low-cost production.
Second, the solution <br> <br> non-PVC film soft bag infusion production processes
Non-PVC film soft bag large infusion production process
As can be seen from the above flow chart, the part that affects the production cost is the mouth tube, cover, membrane and bag filling and potting equipment. At present, there are 3 to 4 domestic production bag making and potting equipment, but most of them Still in the imitation stage, its stability and economy are not ideal. After a large amount of design and use experience, Huiyi Pharmaceutical has made bold improvements and innovations to the equipment. The world is the first to adopt a two-in-one structure. The pipe is only clamped once, and the printing, bag making, filling, sealing and other processes are completed on the same conveyor belt, which avoids the transfer and transfer of the empty bag between the bag making and the potting, which simplifies the transmission link and greatly reduces the number of transmissions. The failure rate of the device improves the stability of the device. At the same time, it also avoids the particles generated by the nozzles of similar equipment that need to slide in the fixture and transfer 7-8 times of friction, which greatly improves the safety of the pharmaceutical. In addition, because the length of the equipment is shortened and only one electric control box is used (others include The imported equipments are all 2 electric control boxes, which greatly saves the plant area and reduces the operating cost of air-conditioning purification, reducing one operator. In terms of membrane saving, we have adopted the global* non-waste patent technology on the equipment mold, so that no waste edge is produced between the bag and the bag, and between the group and the group. At the same time, we have existing bags at home and abroad. The models have been compared and optimized so that each piece of equipment can reduce production costs by 60 to 1 million per year due to film savings. We have also greatly improved the accuracy of the mold and the temperature control accuracy, so that the equipment can be applied to the three-layer, five-layer and imported three-layer and five-layer films, which enables users to have a variety of choices for the film to reduce the cost of use. At the same time, because of the improvement of precision and stability, the qualification rate of the product is greatly improved, and the leakage rate is greatly reduced. According to the usage statistics of Shuanghe Pharmaceutical (three consecutive purchases of Huiyi soft bag line from March to October 2010), the product qualification rate is above 99%, the bag leakage rate is below one ten thousandth, and the small size is up to One hundred thousandth or less. Moreover, the equipment basically does not have a downtime condition. At present, Huiyi Pharmaceutical has formed a series of non-PVC membrane infusion production lines with single and double-mouth tubes 1, 2, 3, 4, 6, and 12 heads, and a follow-up automatic bag handling system. 15,000 bags / hour, the annual output can reach more than 70 million bags, is the current global production line of zui, fully adapted to large-scale production requirements.
Blowing film was once a relatively difficult technology to master. Three years ago, non-PVC film basically relied on imports, but at present, a five-layer film manufacturer represented by Shuangjin and Taibang has been formed in China and Ou Xing and Chang Jian. As a representative of the three-layer film manufacturer, in addition, there are more membrane plants that have been built and are being prepared, which shows that the Chinese people have gradually mastered the film production technology. With the technology and experience in the large infusion industry, Huiyi Pharmaceutical Co., Ltd. has jointly developed the CM3/5-600 blown film system with the European professional blown film equipment factory. The annual output of the single machine is about 600 tons, and the 250ml bag can be made more than 80 million. Each bag of products can save more than 0.2 yuan compared with the current market, and the annual savings are more than 16 million yuan.
The production technology of mouth tube and lid is relatively simple and mature, and some pharmaceutical factories have already made it. The pipe mouth weighs about 3.3g, the inner cover is 0.9g, and the outer cover 2.4g plus rubber pad has a full production cost of about 0.2 yuan.
Purchase and self-made tube cover film bag cost comparison table
Blowing film was once a relatively difficult technology to master. Three years ago, non-PVC film basically relied on imports, but at present, a five-layer film manufacturer represented by Shuangjin and Taibang has been formed in China and Ou Xing and Chang Jian. As a representative of the three-layer film manufacturer, in addition, there are more membrane plants that have been built and are being prepared, which shows that the Chinese people have gradually mastered the film production technology. With the technology and experience in the large infusion industry, Huiyi Pharmaceutical Co., Ltd. has jointly developed the CM3/5-600 blown film system with the European professional blown film equipment factory. The annual output of the single machine is about 600 tons, and the 250ml bag can be made more than 80 million. Each bag of products can save more than 0.2 yuan compared with the current market, and the annual savings are more than 16 million yuan.
The production technology of mouth tube and lid is relatively simple and mature, and some pharmaceutical factories have already made it. The pipe mouth weighs about 3.3g, the inner cover is 0.9g, and the outer cover 2.4g plus rubber pad has a full production cost of about 0.2 yuan.
Purchase and self-made tube cover film bag cost comparison table
Purchase and self-made tube cover film bag cost comparison table
As can be seen from the above table, the packaging cost of the large infusion of the self-made mouth tube, cap, and membrane soft bag can be basically equal to or even lower than that of the glass bottle.
Annual production of 70 million bags of non-PVC film soft bag large infusion project main equipment investment table unit: 10,000 yuan
Annual equipment production table of 70 million bags of non-PVC film soft bag large infusion project
The entire project can be fully recovered within one year after the project is completed.
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