In 1994, the International Association of Alzheimer's Association held its tenth meeting in Edinburgh, England, and identified September 21st of each year as World Alzheimer's Day. In 2001, China hosted the “World Alzheimer's Disease Awareness Day†for the first time. The theme at the time was: “Diagnosis of dementia, the first step to effective help.†However, even after 17 years, the diagnosis of Alzheimer's disease is not Easy.
The scientific name of Alzheimer's disease is Alzheimer's disease (hereinafter referred to as AD), and aβ42, total tau and P-tau are clinically used as three biomarkers for determining AD. These three markers belong to macromolecular proteins and cannot penetrate into the blood circulation through the blood-brain barrier of the human body. Therefore, the traditional detection method is to collect the cerebrospinal fluid of the patient for measurement.
When doing cerebrospinal fluid testing, patients need to be admitted to hospital for puncture surgery and are expensive. It is understood that the cost of a cerebrospinal fluid test is more than 2,000 yuan, and if you want to use the most advanced equipment, it will cost more than 8,000 yuan. AD is an irreversible neurodegenerative disease, and its clinical symptoms will not appear until the middle and late stages, which makes expensive cerebrospinal fluid detection appear ribs.
According to statistics, every 3 seconds, one person in the world is diagnosed with AD. The number of AD patients in China has exceeded 10 million, and it is growing at a rate of 300,000 per year. In 2015, the National Institutes of Health (NIH) conducted statistics. The direct costs of AD diagnosis and treatment in the United States totaled more than $800 billion, and this figure is expected to reach $20 trillion by 2030.
Small molecule mass spectrometry, perhaps the most accurate disease screening method
Dr. Li Lin, the founder of Haosi Bio, told the arterial network that some small metabolic molecules in the blood can also be used to accurately diagnose AD, but traditional detection methods cannot capture them. Based on mass spectrometry, Haus Bio has developed a completely new solution.
Mass spectrometry and gene sequencing are the underlying technologies for precision medicine . Gene sequencing is a technique for the determination of genomics, while mass spectrometry is used for the determination of metabolomics. Often, genomics information determines an individual's genetic traits, while metabolomics characterization can provide information about an individual's illness.
At present, the application of mass spectrometry is far less popular than the sequencing of genes. The most common mass spectrometry test is newborn screening. At present, nearly 30% of newborn screening in the country uses mass spectrometry, while the United States uses mass spectrometry to complete this screening.
Dr. Li Lin believes that the low popularity of mass spectrometry is caused by the complexity of traditional mass spectrometry methods, and providing a standardized mass spectrometry kit is a good way out.
It is understood that Dr. Li Lin graduated from Peking University with a bachelor degree and studied in Europe and America for 7 years. He has more than 10 years of experience in mass spectrometry platform research and has published 34 international academic articles.
In 2015, Dr. Li Lin was introduced back to China by Professor Shi Yigong, Vice President of Tsinghua University. After returning home, her first thing was to localize the mass spectrometry and select the latest AD mass spectrometry. To this end, Dr. Li Lin and her team developed a mass spectrometry-based AD kit that took three years to track down. So far, the team has completed 400 clinical trials.
Haosi Bio's AD Diagnostic Kit uses liquid chromatography-tandem mass spectrometry (LC-MS/MS) to detect 8 biomarkers in plasma. The test results are much larger than the information given by the traditional cerebrospinal fluid. Early diagnosis, staging, monitoring of the progression of dementia disease and evaluation of treatment effects. And the AD diagnostic kit takes venous blood without requiring the patient to be admitted to the hospital, and has the advantages of simple operation, reasonable cost, and high accuracy.
In addition, Haus Bio's products include the CERAM kit and the Prostate AA kit. Among them, the CERAM kit is used for cardiovascular disease screening and diagnosis. Unlike traditional cardiovascular disease screening, which focuses on biochemical tests for 5 lipids and multiple related proteases, the CERAM kit detects blood. The content of four ceramides, which are subtypes of phospholipids with higher sensitivity and specificity, greatly reduce the risk of misdiagnosis.
The Prostate AA kit is used for early screening for prostate cancer diagnosis. At present, the most commonly used diagnosis method for prostate cancer is serum prostate specific antigen (PSA) detection, and the false positive rate of PSA is high. The Prostate AA kit is based on a metabolomics platform that uses LC-MS/MS to help clinicians determine whether a patient needs to perform or re-examine a prostate biopsy, especially if the rectal digital is negative and the PSA level is not elevated.
“The CERAM kit has been approved for Class II medical devices and has begun to enter several top-level top three hospital departments.†Dr. Li Lin said that the products of Haus Bio have entered the market layout stage. In the landing stage, Haosi Bio has differentiated its service objects into high-end, mid-range and low-end to provide differentiated service types. “High-end brands, mid-end market, low-end popularization.†Dr. Li Lin stressed that Haus The ultimate goal of biology is to bring precision medicine based on mass spectrometry detection to the entire medical system in China.
Push precision medicine to the grassroots with standardized kits
According to Dr. Li Lin, since the traditional detection methods can not meet the requirements of accuracy and specificity of medical diagnosis, the acceptance of the products on the market is very good. In addition, Haosi Bio has a 3,000-square-meter GMP workshop in Jiangsu for the production of kits, of which 1,500 square meters have been put into production, and the annual production capacity is expected to reach about one billion.
High-end market. Haosi Biotechnology Co., Ltd. cooperates with mature mass spectrometry laboratories and professional teams. For example, the top three teaching hospitals, maternal and child specialist hospitals, and third-party clinical inspection centers have been established through the establishment of “Hauss Labâ€. At present, Haosi Bio has established a fully licensed third-party clinical inspection center in Nanchong, Sichuan, and Beijing's fully licensed third-party clinical inspection center is also in preparation. In the next three years, Haosi Biotech plans to set up five fully licensed third-party clinical inspection centers throughout the country as an entry point to introduce the most advanced mass spectrometry detection kits from abroad.
Mid-market segment. House Bio will provide kit products and operations services for medical facilities that have installed mass spectrometry laboratories and purchased general-purpose equipment. Li Lin told the arterial network: "Most of the domestic hospitals, specialist hospitals and maternal and child health hospitals meet such conditions." In addition, the kits of Haus Bio are designed to be highly compatible with existing mass spectrometry equipment.
Low-end market. The company's solution is to provide standardized products to the grassroots specialty specialists to simplify medical testing. Primary medical institutions are important carriers for people's health management. The kits for therapeutic drug testing and nutritional status assessment of Haus Bio will help to promote health management accuracy.
Haus Bio is currently undergoing Series B financing, and has previously obtained two rounds of financing including the Real Fund, Volcanic Stone Capital, and Huachuang Capital.
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Red light therapy benefits and what is red light therapy?
The function of a red light therapy bed machine is to emit low-level red and near-infrared light wavelengths onto the body. This therapy is believed to stimulate the production of collagen, increase blood circulation, and promote healing in the skin and other tissues. It is used for various purposes, including reducing wrinkles and fine lines, improving skin tone and texture, reducing joint pain and inflammation, and promoting overall well-being.
A safe, all natural process that encourages your body to naturally produce enzymes, elastin fibers and collagen that support the skin`s structure. Thus producing younger, smoother and firmer feeling skin. Here are some common questions that our members often ask about Red Light Therapy:
FAQ of red light bed machine
Q:What should I do before use the bed?
A:Before you begin: Thoroughly cleanse your skin with a gentle, non-drying cleanser. Remove any mineral-based sunscreen, as well as makeup containing zinc or other mineral-based sunscreens. In general, sunscreen won't block red/NIR wavelengths. However, zinc oxide reflects light, which means there's a chance that fewer therapeutic light photons will be available to absorb into the skin. Alternatively, administer the therapy first thing in the morning, before applying any skincare products.
Q: What is red light therapy used for?
A:Red light therapy is used to treat injuries, reduce pain, relax muscles/joints, and increase blood circulation. It is typically used by doctors, physical therapists, and pain clinics as a highly effective non-invasive treatment with no known side effects. It also used by professional athletes to improve performance and reduce the incidence of injuries.
Q:How often can you use red light therapy?
A:You can use red light therapy every day. Most people don't see much benefit using it more than once per day. For handheld treatments your practioner will advise you as to your treatment plan.
Q:How does light energy work?
A: Specific wavelengths of light energy, when properly absorbed, up-regulates compromised cells. The light (photons) energy is absorbed by photoacceptors in the mitochondria and used to create adenosine triphosphate (ATP). The ATP produced then stimulates various metabolic processes which can result in the repair and regeneration of cell and tissue components.
Q: Can this hurt my eyes?
A:The typical human eye responds to wavelengths 400nm to 700nm. The light coming from this device is either visible red or invisible infrared.
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