Recently, Zhu Shiguo, a team of the School of Basic Medicine of Shanghai University of Traditional Chinese Medicine, published an online research in the international academic journal Autophagy. The results of the research by Dr. Yao Chao, the first author of the team, showed that amide-enhanced natural killer cells (NK cells) Killing effect of non-small cell lung cancer cells. The research results have been declared national invention patents.
NK cell immunotherapy is a promising new method of tumor immunotherapy, but cancer cell immune escape limits the clinical effects of NK cells. How to improve the anti-tumor effect of NK cells is an important frontier topic of current tumor immunotherapy.
The team of Zhu Shiguo has an in vitro expansion technology of NK cells with independent intellectual property rights, which can guarantee the clinical supply of NK cells in number. In order to find out the active ingredients of traditional Chinese medicines that improve the anti-cancer effect of NK cells, the team has established a variety of high-throughput screening systems, and through these systems, found a variety of potentially valuable Chinese medicine active ingredients.
This time, the team has been extensively screened and closely identified. It has been found from thousands of traditional Chinese medicine active ingredients that the active ingredient amide amide has a good ability to improve the anti-tumor effect of NK cells. It has been found that amide can bind to the specific sequence of the 5' untranslated region of the autophagy initiation factor ULK1 messenger RNA, repress the translation of ULK1 protein, thereby inhibiting autophagy of tumor cells and increasing the granzyme B derived from NK cells in tumor cells. Level, thereby blocking autophagy-mediated tumor immune escape, and ultimately increasing the killing effect of NK cells on tumor cells. The results of this study have important application prospects in the field of tumor immunotherapy, especially NK cell immunotherapy.
It is understood that M. chinensis is an evergreen shrub or small tree belonging to the genus Corydalis, native to southern China, and its chemical composition includes lignans and diamides. The branches and leaves of Mi Zilan are used as medicine for the treatment of bruises and hemorrhoids. Its flower is used for qi stagnation and chest tightness. (Special correspondent Wang Ziying correspondent Jiang Tao)
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