Broccoli extract inhibits bladder cancer cells

According to the "Science and Technology Blog" website reported on July 28, US researchers believe that compounds extracted from broccoli can prevent or slow the growth of bladder cancer cells. Experiments conducted by Harvard University and Ohio State University showed that eating two or more broccoli per week is 40% less likely to suffer from bladder cancer than eating a broccoli. Steven Schwartz, a professor of the Department of Food Science and Technology at Ohio State University, said: "We are investigating which compound is inhibiting bladder cancer." "Understanding this information can help us build a healthier medical system. Sexual recipes will be much more beneficial to patients than simply eating foods according to food,” he said. In the United States, there are more than 63,000 people suffering from bladder cancer each year and 13,000 people have died of the disease. The researchers extracted a compound called glucosinolates from the broccoli sprouts. After a series of reactions such as chewing and digestion, this substance has become isothiocyanates. Scientists believe that this is a substance that inhibits the growth of cancer cells. Their assumption is correct, and the laboratory's results confirm this assumption. Therefore, isothiocyanates can indeed prevent the growth of bladder cancer cells, and its characteristics have also been confirmed on the most destructive bladder cancer cells. At the annual food science and technology conference held in New Orleans, researchers announced the results of this research. The testers first extracted glucose isothiocyanate from broccoli sprouts, and then used enzymes to catalyze the change of extracted glucosinolates to isothiocyanates. Schwartz said: "The tender broccoli contains more isothiocyanate than the mature broccoli. Therefore, eating more tender stems is more beneficial to the body." He and his colleagues took different doses of glucose isothiocyanate. And isothiocyanates were tested on two groups of human bladder cancer cells and a group of mouse cells. Although glucosinolates have been converted to isothiocyanates in these tests, scientists still hope to obtain useful information from experiments on human bladder cancer cells. In all three cell experiments, isothiocyanates reduced cell proliferation. Among them, the most intense manifestations were in human group cancer cells. The experimenters still do not know what is the internal reason why the thiocyanate reduces the ability of cells to reproduce, and it is not clear how these compounds prevent the proliferation of cancer cells. They are conducting further research on this. Professor Steven Clinton, a professor of blood and oncology at Ohio State University and one of the researchers of the trial, said: "We can't say that only broccoli has anti-cancer substances. At least a dozen related plants have this substance. "We are studying more similar substances to see if they are intrinsically linked and to study their performance on cancer cells," he added. The researchers said that broccoli is not the only health-friendly cruciferous plant. Close relatives of broccoli, like cabbage, broccoli, Brussels sprouts, and kale all contain the same anti-cancer substances. Broccoli and similar plants have a lot of benefits in delaying the spread of bladder cancer cells. They are also very important in our daily food. Schwartz said: "Cruciferous plants also play a role in other cancers. We have found that it can eliminate the toxicity of some carcinogens. We want more to control the division of cancer cells. When they begin to spread, there is no What are some good ways to block or slow this spread?” He and Clinton led the study. Ronbin Rosselot, a graduate student in the Department of Food Science and Technology at the University of Ohio, and Qinggu, another graduate student in the department, also participated in this study. test. Researchers isolated from broccoli compounds that are believed to help prevent or alleviate the progression of bladder cancer. The results of the study were announced at the annual Institute of Food Technologists meeting in New Orleans on July 18th. The new study was based on an important study of Harvard and Ohio University six years ago. A 6-year study found that men who consumed more than two broccoli per week had a 44% lower risk of developing bladder cancer than men who ate broccoli less than once a week. Researchers isolated a class of compounds called glucosinolates from broccoli buds. During chewing and digestion, these compounds become very nutritious isothiocyanates - researchers believe this compound plays a role in the suppression of cancer. In the experiment, this prediction was confirmed: isothiocyanate can inhibit the growth of bladder cancer cells. And the best effect is on the most aggressive forms of bladder cancer. They first extracted and measured the glucosinolate levels in the broccoli sprouts. Then, they used some enzymes to convert glucosinolates to isothiocyanates. The researchers treated two human bladder cancer cell lines and mouse cell lines with different amounts of iso- glucosinolate and thiocyanate. The results showed that thiocyanate reduced the expansion of the three cell lines and the strongest effect was shown on the most aggressive cell lines. Researchers have not been able to determine what caused this effect or the exact mechanism by which these compounds make cancer cells unable to expand. At present, they are continuing to study in depth in order to answer these questions at an early date.

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