Release date: 2015-10-29
The international research team published a paper in the latest issue of Applied Chemistry, which designed and synthesized a nanoscale DNA (deoxyribonucleic acid) machine with custom-modified features that support the identification of specific target antibodies.
The international research team published a paper in the latest issue of Applied Chemistry, which designed and synthesized a nanoscale DNA (deoxyribonucleic acid) machine with custom-modified features that support the identification of specific target antibodies. The research results will revolutionize the current slow, cumbersome and expensive antibody detection process, and help diagnose rheumatoid arthritis, HIV (HIV) infections and other autoimmune diseases, thereby reducing disease treatment delays and reducing Treatment expenses.
The paper points out that the binding of antibodies to the DNA machine can cause structural changes and produce optical signals. The sensor does not require chemical activation and can act quickly in less than 5 minutes, making it easy to detect target antibodies even in complex clinical samples such as serum.
Professor Valery Belliso of the University of Montreal in Canada said that the modular platform has obvious advantages over existing antibody detection methods, not only quickly, but also without chemical reagents, and can be used in a series of occasions such as instant detection and biological imaging. The researchers also said that the method is broad-spectrum and very flexible, and DNA nanomachines can be customized to detect antibodies against a variety of different diseases. The platform also has the advantage of low cost, with a cost of only 15 cents per test, which is very competitive with other quantitative methods.
At present, researchers are working with the diagnostic company to improve the technology. By adjusting the platform, users will be able to directly read the nanoswitch signal from the mobile phone in the future.
Source: China Science and Technology Network - Technology Daily
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