Recently, the "Nature" publication published a research, the Frederick Hutchinson Cancer Research Center in Seattle, USA, developed a biodegradable nanoparticle that can program T cells in vivo to recognize and attack cancer cells. The study found that T cells (immune cells) programmed by nanoparticles can quickly remove cancer cells from leukemia mice and alleviate the progression of mice.
As far as is known, this is the first time that T cells are rapidly programmed in vivo (no need to extract T cells in the laboratory), and reprogrammed T cells can begin to function within 24 hours to 48 hours, and in a few weeks These receptors that recognize tumor cells continue to be produced over time. Allows the immune system to quickly produce a strong enough response to kill cancer cells early.
A cross-section of the nanoparticles designed by Dr. Matthias Stephan and his team shows the T-package programming genes in the inner packaging. The yellow molecules coated with the particles help them adhere to the T cells. Orange polymers help bind and carry genes into the nucleus.
Subverting tradition, first in vivo transformation of T cells
Cellular immunotherapy has shown broad application prospects in clinical trials, but the challenge has always been to make them more widely available and to deploy them quickly.
Stephan built his T-cellhoming nanoparticle to help more patients benefit from cancer cell immunotherapy.
Although cell-based killer immunotherapy is currently only available through clinical trials, it has great potential for certain leukemia patients with tumors that conflict with conventional treatments. T cells attack cancer cells, which is undoubtedly the best breakthrough for researchers to create live anticancer therapy.
CAR-T therapy (chimeric antigen receptor T cells) has emerged, similar to other immunotherapies. Its basic principle is to use the patient's own immune cells to clear cancer cells. The key to this new treatment strategy is that An artificial receptor called a chimeric antigen receptor (CAR) that recognizes a target cell, and after genetic modification, a patient T cell can express such a CAR.
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