Adult stem cells can regenerate the heart of a patient

The University of New Otani's research provides a new insight into heart repair, which is how heart patients can use their adult stem cells to regenerate their diseased heart.

Adult stem cells can regenerate the heart of a patient

The study, led by physiologic researcher Dr. Rajesh Katare, was the first to study the potential of heart repair using three types of stem cells from individual patients.

In recent years, the method of extracting and transplanting patients' own stem cells to help patients with heart repair has already attracted great research interest internationally. However, determining the optimal cell type to use remains a huge challenge.

To help overcome this challenge, Dr. Katare and his team used stem cells from 14 patients undergoing coronary artery bypass graft surgery to compare the function of three types of adult stem cells. These three types of stem cells have two hearts from the patient itself - the left ventricle and the right atrium - and the third from the same patient's circulating blood.

Under the experimental conditions, the researchers simulated the hypoxic levels of the patient's heart and the conditions of lack of nutrients. He and his colleagues then studied the therapeutic effects of repairing damaged heart cells by each of the three stem cell types.

They found that right atrial stem cells have the greatest protective effect on cardiomyocytes, and ventricular stem cells are most effective in promoting new blood vessel formation.

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