New research: breakthrough technology can speed up the drug development process

[China Pharmaceutical Network Technology News] Recently, researchers from Indiana University have designed a new method that can fundamentally accelerate the synthetic development of new compounds.

The synthesis of useful new compounds is the work of pharmaceutical companies to discover and develop. The research on this new method is published in the international journal Nature Chemistry.


In the article, the researchers designed and tested a novel molecular binding technique that effectively shortens or simplifies the discovery and development of human and animal drugs. This new technology is developing new drugs compared to current methods. It is also more economical and environmentally friendly. This new synthetic method can be used to synthesize a series of compounds containing nitrogen. About 75% of pharmaceutical compounds use nitrogen atoms, and such drugs are also used to treat a range of diseases, including cancer, bacterial infections, inflammatory diseases, Attention deficit/hyperextension syndrome, Alzheimer's disease, and diabetes.

Drugs are compounds with different combinations of atomic arrangements. Compared to traditional methods, this new drug synthesis method can take fewer steps of chemical synthesis, which can potentially develop second-generation new drugs and develop new drugs. therapy. Researcher Ge pointed out that due to the fewer synthetic steps and simple chemical composition, the new method we developed has certain beneficial effects for the pharmaceutical industry and patients, and this new technology is superior to the drugs currently used. resolve resolution.

Now researchers are in the early stages of research, using this new method to successfully synthesize the analog of Fingolimod, a drug used to treat recurrent multiple sclerosis; researchers It is pointed out that hydrocarbons are used at any time in our daily life, such as clothes and toothbrushes. These compounds are generally stable and do not react with common compounds, transforming one hydrocarbon into another. It is an innovative field for researchers to develop new materials.

Finally, the researcher Basu said that the use of selective methods to achieve compound transformation has been a major challenge for scientists for more than a century. The new technology developed by researchers in this research may promote the development of new drugs in the future. New research ideas and clues are provided to reduce the time and cost of drug development.

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