Release date: 2017-02-15
A cancer research achievement of the Chen Zhiying team of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences and Huada Gene was published in the journal Cancer Medicine. The project developed an electronic computer algorithm that used cancer genomics to construct a "cancer antigen tree" for 23 Chinese women with early cervical cancer, with the goal of helping to find the best cancer immunotherapy target to improve efficacy.
Scientists use the mutations and mutations of human genes to inherit the two characteristics of the offspring, make the conclusion that human originated in Africa, and draw a road map out of Africa to evolve different races. In addition to different skin colors, human races have different sensitivities to disease and treatment. Similarly, cancer originates in a cell and is the result of the accumulation of genetic mutations that produce many new targets and become unique and ideal therapeutic targets for cancer cells without harming normal cells. As mutations continue to occur, many cell populations are derived, and different cell populations have different combinations of targets and respond differently to treatment. Most of the current immunotherapy is only for a part of the cell population. For solid tumors, the tumor can be narrowed and the disease is stable, but the residual cancer cell population continues to grow and soon relapses.
"Cancer Antigen Tree" is the team's data based on cancer genomics to find out the evolutionary relationship between all cell populations and their targets in a cancer, helping to determine the common target of all cancer cells on the "trunk", greatly Improve the efficacy. This algorithm has important guiding significance for guiding the development of a new generation of cancer immunotherapy technology. The project is part of the team's "microcircle DNA gene vector cancer immunotherapy technology platform" to develop safe, efficient, convenient and affordable anti-cancer gene drugs.
Source: Chinese Journal of Science
API Powder (Active Pharmaceutical Ingredient)
Active Pharmaceutical Ingredients refer to the raw materials used in the production of various preparations. They are the effective ingredients in the preparations. They are various powders, crystals, extracts, etc., prepared by chemical synthesis, plant extraction or biotechnology, but Substances that the patient cannot take directly.
According to its source,Active Pharmaceutical Ingredients are divided into two categories: synthetic chemical drugs and natural chemical drugs.Chemical synthetic drugs can be divided into inorganic synthetic drugs and organic synthetic drugs. Inorganic synthetic drugs are inorganic compounds (extremely elements), such as aluminum hydroxide and magnesium trisilicate used to treat gastric and duodenal ulcers; organic synthetic drugs are mainly composed of basic organic chemical raw materials, through a series of organic Drugs made by chemical reactions (such as aspirin, chloramphenicol, caffeine, etc.).
Natural chemical drugs can also be divided into biochemical drugs and phytochemical drugs according to their sources.Antibiotics are generally made by microbial fermentation, which belongs to the category of biochemistry.In recent years, many semisynthetic antibiotics are the combination of biosynthesis and chemosynthesis.Among APIs, organic synthetic drugs account for the largest proportion in variety, yield and output value, which is the main pillar of chemical pharmaceutical industry.The quality of API determines the quality of preparation, so its quality standards are very strict. All countries in the world have formulated strict national pharmacopoeia standards and quality control methods for its widely used API
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