Recently, a research report published in the international magazine Nature Communications, researchers from the University of Kentucky found that under certain genetic conditions, a non-small cell lung cancer may be transformed into another lung cancer subtype. .
The lineage switch of lung cancer is resistant to some cancer therapies. In this study, the researchers specifically examined the mechanism by which this lineage switch occurred. In previous studies, the researchers did not know which cells in the adult lungs are the cell origins of the two major subtypes of non-small cell lung cancer, the two major lung cancer subtypes are adenocarcinoma and squamous cell carcinoma; Similarly, researchers are not aware of the differences in DNA assembly between different lung cancer subtypes. The presence of lung adenocarcinoma is clinically defined as the presence of all adenocarcinoma lesions, and there is a marked stratification of squamous lesions in the same tumor, suggesting that lung adenocarcinoma and squamous cell carcinoma may be from the lungs. The same cells in the organization, but the current researchers lack clear evidence to confirm this.
In this study, the researchers found that lung adenocarcinoma cells can be reassembled in a special way to transform into squamous cell carcinoma of the lung. By studying the mouse model of adenocarcinoma lung tumors, the researchers will This is inherited from human adenocarcinoma lung tumors. Human adenocarcinoma lung tumors are genetically identical to mice, including activation of oncogene KRAS and tumor suppression from Lkb1; Subsequently, the researchers conducted a transplant test and found that in the mouse body, the established lung adenocarcinoma tumor can be transformed into lung squamous cell carcinoma.
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