Ganoderma lucidum gene veil unveiled
July 06, 2015 Source: Xinhuanet
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Ganoderma lucidum is one of the “Four Great Grasses†in traditional medicine. On the 2nd, the reporter learned from the Chinese Academy of Chinese Medical Sciences that the research team led by Chen Shilin, head of the Education Department's Jiang Scholar Innovation Team, completed the fine map of the Zizhi genome, which contains 12 chromosomes with a total length of 48.86 megabases and a code of about 1.5. Ten thousand genes. Relevant research results have been published in the journal Science Report of the Nature Publishing Group.
The research group showed that Zizhi has multiple defense mechanisms in its growth and development, including genomic defense mechanism and chemical defense mechanism. The chemical defense function of Zizhi may be affected by various gene regulation mechanisms. Genomic defense is important for maintaining the stability of genetic material in a species, and chemical defense is closely related to the synthesis and regulation of its secondary metabolites.
This study lays a solid foundation for the study of the secondary metabolism and growth of Ganoderma lucidum by comparative genomics, and then cultivates excellent varieties through molecular breeding. According to Dr. Zhu Yingjie, the first author of the paper and the Institute of Chinese Medicine of China Academy of Chinese Medical Sciences, although the genomes of Ganoderma lucidum and Zizhi have high similarity, the skeleton synthetase and modified enzymes associated with secondary metabolism have obvious Difference, this may be the genetic basis of the different metabolite profiles of Ganoderma lucidum and G. lucidum and their pharmaceutical efficacy.
It is reported that the research team has taken the lead in completing the detailed map analysis of the Ganoderma genome at the chromosome level and proposed that Ganoderma lucidum is a medicinal model species. The article was published in Nature Communication and was selected as the best research in China by the natural website. The publication of the Ganoderma lucidum genome map facilitates the synthesis of active constituents such as Ganoderma lucidum, and with the gradual analysis of these synthetic pathways, it is possible to synthesize the active ingredients of Ganoderma lucidum by synthetic biology. At the same time, the discovery and recognition of Ganoderma lucidum growth and development and resistance and stress resistance genes will promote the genome-assisted breeding of Ganoderma lucidum, accelerate the cultivation of new Ganoderma lucidum varieties, and provide theoretical guidance for the scientific cultivation and harvesting of Ganoderma lucidum.
Plant extracts are substances extracted or processed from all or a part of plants as raw materials using appropriate solvents or methods, which can be used in the pharmaceutical industry, food industry, health industry, beauty industry and other industries. Plant extracts mainly take plants as raw materials, according to the needs of the use of the extracted final products, through the process of physical and chemical extraction, extraction and separation, directional acquisition and concentration of one or more effective components in plants, without changing the structure of its effective components and the formation of products. According to the different components of extracted plants, glucosides, acids, polyphenols, polysaccharides, terpenoids, flavonoids, alkaloids, etc.; According to different characters, it can be divided into vegetable oil, extract, powder, lens and so on. The plant extract industry has developed in the last 20 years and is used in the pharmaceutical, fine chemical and agricultural industries.
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