Chinese scientists first analyze the whole process of homing of hematopoietic stem cells in vivo
November 21, 2018 Source: China Youth Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Pan Yujun, a researcher at the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, led his research team to directly observe the complete dynamic process of hematopoietic stem cell homing in the world. The research results were published online in the international academic journal Nature on November 20th, Beijing time. .
Hematopoietic stem cell transplantation is the hope of many malignant tumors, immune and blood diseases patients to regain their vitality. Improving the success rate of transplantation has always been the goal pursued by life scientists and doctors. However, hematopoietic stem cells must enter the hematopoietic tissue in order to produce "offspring" such as red blood cells, white blood cells, and platelets. This process is called "homing."
Although researchers have made some analysis of the cellular and molecular basis of homing during the past few decades of research, how does homing occur in the physiological state of the body, and what kind of structure does the homing microenvironment have? A series of key scientific principles such as how microenvironment cells help hematopoietic stem cells homing remain poorly understood, severely restricting the development of related technologies such as clinical hematopoietic stem cell transplantation.
Pan Yijun led his team for 6 years. Based on the optimization of living imaging technology, he further integrated the methods of living immunofluorescence labeling, genetic regulation and graphic reconstruction calculation, and created a new set of new methods for the complete analysis of the process of hematopoietic stem cell homing in vivo. Research system.
During the course of the study, they also accidentally discovered a brand new microenvironmental cell and named it "leader cell." These cells are a previously undefined macrophage new subtype that exists near the homing "hot spot" and recognizes hematopoietic stem cells that enter hematopoietic tissue and introduces them into specific vascular structures. The homing of hematopoietic stem cells.
This is an original scientific discovery independently completed by Chinese scientists, which has opened up a new era of long-term, high-resolution research in the field of hematopoietic stem cells in the world.
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