Release date: 2015-04-17
Recently, researchers from West Virginia University have shown that antioxidants may play an important role in the long-term effects of concussions, and that they may be able to help develop new therapies for concussion.
Concussion is more common among athletes and soldiers. It is estimated that there are approximately 3.4 million concussed patients in the United States each year, and the development of oral supplements may potentially improve the brain function of a certain proportion of concussed patients; concussion often leads to chronic Injury encephalopathy, a brain injury usually leads to chronic injurious encephalopathy, which is often accompanied by long-term brain damage and behavioral symptoms such as memory loss, impulsive behavior, depression, and aggression.
Dr. Lucke-Wold said that concussions can cause long-term changes in brain function, and these changes are the main manifestations of cell death, which is most likely caused by oxidative stress. This study shows antioxidants such as lipoic acid. When it is given to a concussion patient, it will reduce the long-term brain loss of the patient.
In the article, the researchers divided the rats into three groups: the non-concussion control group, the study group with concussion, and the concussion study group receiving lipoic acid supplements. After 4 days of concussion, the researchers used an elevated maze to detect Impulsive behavior in rats, concussed mice not treated with lipoic acid showed an increase in impulsive behavior, which often took more time to explore the risky behavior of open space; and the increase in impulsive behavior can also be hidden in the brain. Under the Ministry of Injury, the researchers will report their findings at the annual meeting of the American Society of Pharmacology and Experimental Therapy in 2015.
The results of the study in the rat group treated with lipoic acid supplements revealed a decline in impulsive behavior. This study is very interesting because lipoic acid can help reduce the toxic free radicals that promote cell damage in the rat's body; The mechanisms hidden in the brain may help researchers develop new targeted therapy interventions to reduce brain damage caused by concussions.
Source: Bio Valley
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