Release date: 2015-07-30
Scientific trials of herpes viruses (such as the triggering of poultry Marek's disease) have confirmed a highly controversial theory: some vaccines can survive and evolve a potent virus, giving vaccinators a greater risk of serious illness. The study was published on July 27th in PLoS Biology. Andrew Read, a professor of biotechnology at Penn State University, said the challenge is to determine whether the vaccine will survive the survival of the virus and the harm to the human body.
"Perfect vaccine" and "imperfect vaccine"
Read said that when the vaccine has a perfect effect, such as children's smallpox vaccine, polio, mumps, rubella, measles vaccine, etc., it can prevent the vaccinator from suffering from the disease, or prevent the patient from transmitting the virus to others. These seedlings are a "perfect" vaccine because they are designed to simulate the creation of "perfect immunity" - the product of human survival in certain diseases.
Venugopal Nair, head of the avian influenza virus disease project at the Pirbright Institute, said another vaccine allows a more deadly virus to survive, such as Marek's virus, and the entire poultry industry relies on vaccination to control the epidemic. Strong virus evolution. Researchers refer to this type of vaccine as an "imperfect vaccine."
The "imperfect vaccine" created a virus vulnerability, so vaccinators sometimes get sick. Vaccines have a long enough survival time to spread the virus to others, and the virus can survive and spread in the population. Nair said that in the vaccinated and unvaccinated flock test, it was found that unvaccinated flocks died and the vaccinated flock survived and spread the virus to the same birds. Studies have shown that vaccination with "imperfect vaccines" promotes the evolution of potent strains, making unvaccinated individuals more at risk of contracting the virus.
Marek's was once a small disease that did not cause serious damage to poultry in the 1950s, but now the virus can kill all unvaccinated poultry within ten days due to the evolution of the vaccine-initiated strain. Read said that although Marek's virus is now much more powerful than before, it is becoming more and more rare because almost all flocks are vaccinated during agricultural production. If all the flocks can be vaccinated against the virus, then when the virus becomes a super virus, as long as the vaccine is still effective, it does not have much impact on the poultry.
The development of "next-generation vaccines" for human diseases should be cautious to prevent vaccine "vulnerabilities"
Research on human disease vaccines has been the focus of disease prevention. Read said that we humans have never experienced any infectious diseases, such as poultry viruses, killing as many unvaccinated individuals as possible. But now we are entering the era of "next generation vaccines", but the next generation of vaccines are "vulnerabilities" because they are aimed at diseases that do not produce good immunity to vaccination bodies, such as AIDS and malaria.
Reader said, "Human disease vaccines are the cheapest and the most popular interventions in the public health sector. But the problem with the next generation of vaccines is that if the next generation of vaccines also has "holes" that can promote the evolution of potent strains, then Human hazards can be very large. At present, the detection of “vulnerabilities†in Ebola vaccines that are in clinical trials is crucial. We do not want Ebola to evolve in the same direction as our research.â€
Researchers recommend rigorous monitoring and careful monitoring of next-generation vaccines to prevent the evolution of potent strains from "vulnerability vaccines." Read, "If one day we have a malaria vaccine and an HIV vaccine, we can certainly use it, but if these vaccines are finally proven to be "vulnerability vaccines" and we can't develop a cure for strong viruses, then we will More dangerous."
Read also recommends vaccination to protect individuals. But when the vaccination results in the evolution of a virulent virus into a stronger virus, it will be the biggest hazard for unvaccinated people, because people who are not vaccinated are exposed to a strong virus without any protection. Read finally said that vaccination is necessary!
Source: Bio-Exploration
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