New in vitro fertilization equipment can promote fertility treatment

Release date: 2015-06-01

For couples who have difficulty conceiving in the traditional way, in vitro fertilization (IVF) is another option for families. When the egg and sperm are combined in a test tube, the fertilized egg develops into an embryo and can be implanted into the mother to continue to grow.
The IVF brought miracles to infertile couples, and the inventor of the technology won the Nobel Prize a few years ago. However, in vitro fertilization is time consuming, expensive and often exhausting because there are usually several rounds of embryo implantation before the mother successfully conceives. According to the American Reproductive Medicine Association, the average cost per in vitro fertilization process in the United States is as high as $12,000, which is difficult for many families to pay.
To make in vitro fertilization more effective, researchers at National Tsing Hua University and the National Health Research Institutes have developed a technique to effectively screen fertilized embryos. This technology helps to better lock in fertilized embryos with high survival rates and increase the success rate of in vitro fertilization, thereby reducing the cost of surgery. Their study was published in the Journal of Biological Microfluidics published by the American Physical Society. .
"If the number of in vitro fertilization and embryo transfer is reduced and the success rate is increased, it will help to alleviate the patient's psychological stress," said Chihchen Chen, the research leader. “We are very interested in the main conditions required for embryonic development, and a deeper understanding in this area is to improve the embryo culture.”
Typically, embryos in IVF are implanted in the uterus in a number of drops mixed together. The efficiency of group culture of embryos is high, but it also makes embryo implantation less selective: laboratory technicians cannot judge whether a single embryo in a trace solution can survive.
Taiwanese researchers have developed a method of culturing white mouse embryos on a plate filled with open microtubules. They spread the white mouse embryos over the entire plate so that there is one or two embryos in each microtubule.
The researchers then sealed the nozzle with oil to prevent the embryo from moving between the different microtubes, while the micropipette could still penetrate the oil film to extract the embryo and implant it into the uterus. The microtubule structure gives each embryo a single growing microenvironment that allows researchers to determine the viability of the embryos one by one.
"Embryonics are very sensitive to the environment. Understanding the microenvironment of the embryo allows us to help the embryo grow better and reduce the post-embryonic operations of the embryo," Chen said.
Chen and her colleagues used high-resolution time-lapse imaging to track the development of individual mouse embryos. "Interestingly, even in a small environment like microtubules, embryos can still successfully develop embryo sacs," Chen said.
In addition, the time required for embryonic development to the 4-cell stage and the 8-cell stage is used to accurately predict the likelihood of embryo development into the embryo sac, which provides a simple screening method for subsequent embryo transfer. Choose the early embryos that have the most potential for survival. Embryo implantation with targeted targets reduces the number of fertilized eggs used, while reducing the time and expense of in vitro fertilization.
Although the current research is limited to the white mouse experiment, Chen and her collaborators hope that this technology can be applied to clinical conception one day. "This technique is expected to be used for human in vitro fertilization after experimental conditions have been optimized and clinically validated according to human embryos," Chen said.
　　 Foreign media: Britain becomes the world's first "three parental in vitro fertilization" legalization country
According to a report on February 26, the foreign media said that the UK will become the first country in the world to legalize the in vitro fertilization (IVF) technology.
According to a Reuters report on February 24, doctors say the technology can prevent incurable hereditary diseases, but critics worry that it will lead to "customized babies."
After more than three hours of debate, members of the House of Lords of the British Parliament voted on the 24th and agreed to amend the law to allow this treatment. This is consistent with the vote of the lower house earlier this month.
The treatment, called mitochondrial metastasis, is also called in vitro fertilization because babies born from transgenic embryos will have DNA from parents and a female donor.
The technology was developed to help families with mitochondrial diseases. Worldwide, approximately one in every 6,500 children is affected by such incurable diseases transmitted by the mother.
According to the February 25 issue of the US Public Science website, the UK is now the first country to legalize mitochondrial DNA transfer.
Earlier in February, the lower house of the British Parliament passed the bill with a vote of 282 votes in favor and 12 votes against it; after being submitted to the House of Lords, the bill was passed with a vote of 232 votes in favor. Human clinical trials may begin as early as the end of 2015.
The three-parent in vitro fertilization technology has received a lot of support. The mother inherited the mitochondrial DNA and nuclear DNA to the infant, while the father only inherited the nuclear DNA. Mitochondrial DNA does not carry personality traits, but does carry certain diseases that may be life-threatening. Mothers can avoid the transmission of these diseases by using the donor's mitochondrial DNA, plus the parents' nuclear DNA to breed a healthy embryo.
Discussions on in vitro fertilization of the three parents have been initiated in the United States, but no formal regulations have been applied to this operation.
According to the British "Guardian" website reported on February 25, the United Kingdom became the first country in the world to allow the use of three parental in vitro fertilization techniques to prevent incurable genetic diseases.
The upper house of the British Parliament held a vote on the evening of the 24th, agreeing to amend the law and allow the fertility clinic to implement mitochondrial donation. Infants 6 born through this in vitro fertilization technique will have biological material from both parents and a female donor. The fertility clinic can apply for a license to use this technology from the fall.
Jeremy Faller, a member of the Welkom Foundation, who supports mitochondrial donation research at Newcastle University, said: "Knowing what kind of family care for children with devastating diseases is the most qualified to decide mitochondrial donation for them. Saying whether it is the right choice. The parliament has made this thoughtful and compassionate decision, and given the world’s esteemed British regulatory system to provide appropriate protection, the choice given to these families is commendable.”
Robert Medoccroft, head of the Muscular Dystrophy Campaign, said: "For many women suffering from mitochondrial diseases, this result will change their lives and give them a precious opportunity to give birth to normal children. Let the related diseases disappear in the family lineage and let fewer and fewer people face the devastating effects of the disease."
Sir Winston, a member of the British Labor Party and a fertility expert, delivered a speech in the upper house today, acknowledging that the first patients will be "a step in the dark," but said all the major advances in reproductive technology, such as the now widely accepted body. Fertilization.
Strictly speaking, “three-parent infants” have three biological parents, 99.8% of their genetic material comes from parents and 0.2% from mitochondrial donors.
(2015-02-26 12:54:40)
　　 Japanese cancer-bearing woman thawed 12 years ago, after the egg was fertilized, she gave birth to a baby boy.
BEIJING, Dec. 7 (Xinhua) -- According to Japanese media reports, a woman suffering from cancer in Japan is worried that her treatment of cancer will make her lose her fertility. She will use frozen technology to preserve her eggs. After 12 years, she will use the thawed eggs to complete with her husband's sperm. Fertilization, and put the fertilized eggs back to the mother to give birth, the baby boy was born in August this year.
The woman, 30, had malignant lymphoma in 2001 and was treated with an anticancer agent and bone marrow transplant, but the anticancer agent may prevent her from ovulating. Dr. Sang Masahiro, a doctor of reproductive engineering at the Fertility Support Medical Research Center for women's frozen eggs, revealed that the woman took two eggs in a clinic that treated infertility before being given formal treatment and kept it at 196 degrees Celsius. She underwent a bone marrow transplant a month later and overcame cancer.
The woman was married last year and then in vitro fertilization, so that the thawed eggs and her husband's sperm were fertilized, and a fertilized egg was placed in the uterus to conceive. In August this year, a baby boy was born in a hospital in Nagoya. The other preserved egg was also fertilized successfully and is now frozen again in preparation for the second birth.
(2014-12-07 09:54:11)
　　 Scientists reveal the earlier origin of fertilization in the body
　　 Scientists reveal the "intimate life" of fish more than 300 million years ago, revealing the earlier origin of fertilization in the body
Xinhuanet Beijing October 21st, the reporter recently learned from the Institute of Vertebrate Paleontology and Paleoanthropology of the Chinese Academy of Sciences, the international research team of the Institute's researcher Zhu Min published a new discovery in the latest issue of Nature, revealing 300 million Years ago, the “intimate life” of a pelvis-wearing fish in the Devonian proved that the fertilized reproduction of the body was earlier than previously thought, dating back to the most primitive group of vertebrate vertebrate species known to date. in.
According to reports, the fertilization methods of vertebrates can be divided into two types: in vitro fertilization and in vivo fertilization. Most modern fish and amphibians are fertilized in vitro, while reptiles, birds and mammals are fertilized in the body. Therefore, the general impression is that in vitro fertilization is more primitive, and in vivo fertilization is a more advanced form of fertilization.
Shieldfish is a type of fish that is wrapped in bone "armor". It flourished in the Devonian (about 420 million years ago to about 360 million years ago) and evolved from the Shieldfish. Other jawed vertebrates, including humans. The armored fish is a kind of eccentric scutellaria fish. Their eyes and nostrils are concentrated on the top of the head like a periscope. The pectoral fins grow more like the crab's limbs than the fins. The armored fish is the most primitive Shieldfish and therefore the most primitive vertebrate.
The small-legged fish is a kind of armor fish distributed in China, Scotland and Estonia. The body length is usually only a few centimeters. In recent years, Professor John Lang of Flinders University in Australia and colleagues have examined a large number of small-limb fish fossils and found that some small-limb fish have a pair of strange side branches at the end of the carcass, and some do not. It should be the skeletal part of the male external genitalia, while the fossils of the female small-legged fish do not have this side branch and are replaced by a pair of bone plates.
Scientists speculate on the mating process of small-legged fish: males and females lined up side by side, and the hard pectoral fins with joints twitched each other, just like dancing in a ballroom dance. The male genitals projecting to the side extend below the body of the female fish, and the female fish is held by the bone plate to complete the in vivo fertilization process.
"We now know that fertilized reproduction in the body is widespread in the scutellaria fish, the original mandibular vertebrate, and secondary to the teleost fish, and in terrestrial vertebrates including humans, It evolved again," said Zhu Min.
Scientists say that although the external genitalia of terrestrial vertebrates and squid are not strictly homologous, molecular biology and developmental biology evidence suggests that the reproductive patterns of many animals, including humans, can still be said to be based on Above the body structure that the ancestral ancestors evolved hundreds of millions of years ago.

Source: science.cankaoxiaoxi.com

Tof LiDAR Sensor

Tof(Time-of-flight), is JRT new product, which is a single-point LiDAR sensor. With a micro size of 46x17x7mm, customers can widely use in many Laser Measurement Solutions. The lidar distance sensor can measure 12m short-range. It's great for Unmanned Aerial Systems.Contact Us Now for data sheet.

ToF Sensor,Time of Flight Sensor,LiDAR Distance Sensor,ToF Distance Sensor

Chengdu JRT Meter Technology Co., Ltd , https://www.rangesensors.com