Poor quality
The mortality or low survival rate of seedlings after stocking often occurs in seedlings purchased from other wild plants. Mutton dropping season is generally between December lunar calendar and early February of the following spring. Due to the small size of the mites, in the low temperature and rainy weather, wild fry species will not normally climb out of the beach. The traders who collect wild seedlings will adopt it. Some drugs are sprayed on the beach surface. The young mud snails have become unbearable and have crawled out of the beach. This facilitates the capture of seedlings. However, although these mud screwworms will not die for the time being, their vitality and physical fitness have been greatly affected. It is not easy to drill and dive after stocking. Can easily be washed away by the tide or death, and slow growth.
Very few sellers will shave the shark seedlings with fresh water so that seedlings can gain weight after gaining water. The seedlings after soaking in fresh water appear to be smooth and clean on the surface, with less silt and large individuals. However, the vitality of young mud snails after freshwater soaking is extremely poor, and it is very easy to die within a week. After drilling mudflats, it is not easy to climb. After the death, the painted surface became dark and odorized, which often caused secondary diseases of the coated surface, which caused subsequent batches of stocking stocks to be affected to varying degrees.
In addition, the phenomena of unscientific and unreasonable transport methods, transportation time, and transportation process of seedlings are also common, which is also the reason for the decline in the viability and quality of the seedlings.
Overdosage
Excessive drug use is the direct cause of the death of farmed snails. Although the use of triazophos in beaches has been banned, it has continued to be used in individual areas and is increasingly used. According to the results of laboratory toxicity tests, 1.5ppm triazophos caused symptoms such as paralysis, foot deformity, poor crawling ability, and weak foot adsorption strength in adult snails. However, spraying triazophos at the farm site was far more than this concentration.
One-sided, blind pursuit of high-density stocking is also the cause of death of the mud snail. The performance in the later period of culture is more prominent. With the growth of mud snails, the amount of food consumed increases and the sludge on the mudflats decreases. Because of the lack of food, some of the snails are inhibited from growing, showing slow growth or no growth. Some individuals are still small and have a difference in weight more than twice as fast as the catch season. The death of snails in the harvest season is often a small individual mud snail, which is related to the lack of food, poor nutrition, and weak constitution.
Aquatic aging environment aging, humus accumulates year by year, exceeds the self-purification capacity of the seashore mudflat, and is one of the causes of the disease. A few years ago, there was no large-scale death of the snail breeding, and it grew well, grew fast, and was robust. After 3 to 4 years of continuous breeding, it is extremely prone to death. At present, in the breeding of marine snails, pre-harvest clearing and ploughing are not thorough. Long-term breeding will inevitably lead to aging of the sediment, making the constricting body of the snails worse, their disease-resisting ability weakened, their ability to adapt to changes in the environmental conditions worsen, and they are prone to death. .
Water eutrophication
Local water bodies, beach eutrophication, and frequent appearance of red tides have caused the death of shellfish culture shellfish. The dead shellfish once again contaminated the beach surface, resulting in a large number of secondary pathogenic bacteria and the spread of diseases, resulting in a vicious circle, resulting in even worse beach culture conditions and causing a greater area of ​​death.
API Powder is fully defined in ICH Q7A as any substance or mixture of substances intended for use in the manufacture of pharmaceutical products and, when used in pharmaceutical products, as an active ingredient of pharmaceutical products. Such substances have pharmacological activities or other direct effects in the diagnosis, treatment, symptom relief, management or prevention of disease, or can affect the function or structure of the body. The active ingredient of a medicine. Only when an API is processed into a pharmaceutical preparation can it become a medicine for clinical application.
According to its source, apis are divided into chemical synthetic drugs and natural chemical drugs.
Chemical synthetic drugs can be divided into inorganic synthetic drugs and organic synthetic drugs. Inorganic synthetic drugs are inorganic compounds (very few are elements), such as aluminum hydroxide and magnesium trisilicate for the treatment of gastric and duodenal ulcer, etc. Organic synthetic drugs are mainly made of basic organic chemical raw materials, through a series of organic chemical reactions and drugs (such as aspirin, chloramphenicol, caffeine, etc.).
Natural chemical drugs can also be divided into biochemical drugs and phytochemical drugs according to their sources. Antibiotics are generally produced by microbial fermentation and belong to the category of biochemistry. In recent years, a variety of semi-synthetic antibiotics are the combination of biosynthesis and chemical synthesis products. Among apis, organic synthetic drugs account for the largest proportion of variety, yield and output value, which is the main pillar of chemical pharmaceutical industry. The quality of the API determines the quality of the preparation, so its quality standards are very strict. All countries in the world have formulated strict national pharmacopoeia standards and quality control methods for the widely used APIS.
Specific API after processing -- pharmaceutical preparations
The term API is used mainly in relation to the finished product. Mainly raw materials obtained by chemical processing means, supply raw materials for the production of finished drugs. For example, cefpirome sulfate for injection is a drug, then cefpirome sulfate is an API
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