Indications
Efficacy: qi nourishing; lungs and cough; hemostasis; blood pressure; anti-cancer.
Indications: qi deficiency and blood loss; lung deficiency chronic cough; hemoptysis; blood stasis; blood stasis; bleeding hemorrhoids; women uterine bleeding; hypertension; retinal hemorrhage; cervical cancer; vaginal cancer; bruises.
Effect on the blood circulation system
1. Anticoagulant effect 300% fungus decoction 1ml/100g gavage for 20 days, the experimental results show that the fungus can extend part of the kallikre in white clay time 12.06s, increase plasma antithrombin III activity, with significant anticoagulant effect. Auricularia polysaccharides (50mg/kg) were given intravenously, intraperitoneally, or intragastrically to mice. All of them had obvious anticoagulant effects. In vitro experiments, Auricularia auricula polysaccharides also had a strong anticoagulant activity.
2. Antiplatelet aggregation A phosphate-buffered saline extract of black fungus significantly inhibited ADP-induced platelet aggregation in vitro and blocked the release of 5-hydroxytryptamine from ADP-activated platelets below 16 μmol/L. The anti-platelet effect of black fungus was water-soluble. Sexual. The platelet function began to decrease within 3h after oral administration of 70g black fungus, and continued for 24h. Auricular mycelia acid extraction (10 g/kg in rats or 10 g/kg for 15 days) in vitro (25 mg/ml, 50 mg/ml, and 100 mg (mycelium)/ml) can significantly inhibit ADP induction. Rat platelet aggregation. Alcohol extract 5g/kg, 7g/kg gavage, a total of 15d, can significantly reduce red blood cell electrophoresis time. The results of intraperitoneal injection of acid heteropolysaccharides from Auricularia auriculatus showed that the polysaccharides had the functions of promoting leukocyte increase, anticoagulation and reducing platelets, and its activity increased with decreasing molecular weight of polysaccharides and uronic acid content, ie biological activity was dependent on The solubility of polysaccharides in water.
3. Antithrombotic rabbit oral Auricularia polysaccharide 18.5mg/kg, can significantly prolong the formation of specific thrombus and fibrin thrombus, shorten the thrombus length, reduce the thrombus wet and dry weight, reduce the number of platelets, reduce the platelet adhesion rate and blood viscosity , And can significantly reduce the time of euglenolysis of guinea pigs, reduce plasma fibrinogen levels, increase plasmin activity, the results show that the fungus polysaccharide has a significant anti-thrombotic effect.
Enhance immune function
Auricularia polytrichum can increase spleen index, half hemolytic value (HC50) and rosette formation rate of mice, promote macrophage phagocytosis and lymphocyte transformation. The mycelia of edible fungus was 250mg/kg. The intraperitoneal injection of mice for 7 days could significantly increase the percentage of T lymphocytes in peripheral blood; 400mg/kg, 800mg/kg was injected subcutaneously for 7 days, and the half hemolytic value HC50 caused by cyclophosphamide was reduced to normal. .
Promote biosynthesis
The 100 μg of Auricularia auricula polysaccharides significantly promoted the synthesis of human lymphocyte deoxyribonucleic acid and ribonucleic acid. The intraperitoneal injection of Auricularia auricula polysaccharides into mice at 100 mg/kg for 4 consecutive days had a weaker promoting effect on 3H leucine incorporation into mouse serum proteins.
Reduce arteriosclerosis
Fungus decoction 30g/kg, continuous gavage 20d, fungus polysaccharide 28mg/kg, and even served 8d, can significantly reduce serum triacylglycerol (triglyceride) and serum total cholesterol (TC) levels in hyperlipidemic rats. Improve serum high-density lipoprotein cholesterol (HDL-C) and total cholesterol ratio, and cholesterol-lowering effect. Fungal polysaccharide 180mg/kg orally can prevent the formation of high cholesterol-induced mouse hypercholesterolemia. Daily feeding of cholesterol, plus black fungus 2.5g / only, a total of 90d, there is reduced rabbit plasma cholesterol, lipid peroxide (LPO), thromboxane A2 (TXA2) content, improve the prostacyclin / thromboxane A2 The ratio of (PGI2/TXA2) reduces the effect of atherosclerosis.
anti aging
Rabbits with black fungus 2.5g per day for 90 days can reduce atherosclerosis rabbit oxygen free radicals, liver, heart, brain tissue lipofuscin, plasma lipid peroxides, plasma cholesterol levels and reduce arterial porridge The role of hardened lesions. It is suggested that black fungus may reduce the formation of lipofuscin, a lipid peroxidation product, by lowering plasma cholesterol, so as to maintain the normal metabolism of cells and show an anti-aging effect. Using chemiluminescence analysis, we studied the removal of superoxide free radicals (O-2) produced by enzyme systems and non-enzymatic systems in 50μl, 800μl, and 1000μl of 2.5% black fungus aqueous extracts. There was a dose-effect relationship between them, suggesting that the black fungus water extract contains components that have antioxidant effects. Auricularia auricula polysaccharide 100mg/kg, intraperitoneal injection, continuous 7d, can extend the average swimming time in mice 50.40%, has the ability to enhance the ability of mice to resist fatigue; but also significantly reduce the mouse myocardial tissue lipofuscin content; obviously Increases the specific activity of superoxide dismutase (SOD) in mouse brain and liver tissue; It significantly inhibits the activity of monoamine oxidase B (MAO-B) in isolated brain of mice, and the inhibitory intensity increases with increasing concentration, and can increase Drosophila fly ability. Auricularia polytrichum can significantly prolong the average lifespan of Drosophila, which is 1.26 times that of the control group. After oral administration of Auricularia auricula polysaccharide for 40 days, Drosophila lipofuscin content was observed.
Anti-radiation and anti-inflammatory
Intraperitoneal injection of Auricularia polysaccharide 100mg/kg, 7d continuous exposure to 60Co γ-ray irradiation antagonistic effect, the survival rate of mice increased 1.56-fold, intraperitoneal injection of 60mg / only, there is a certain resistance to rat paw swelling caused by egg white Inflammation.
Antiulcer effect
The Auricularia auricula polysaccharides were given daily at 70mg/kg for 2 days, which could obviously inhibit the formation of stress ulcers in rats; The rats were treated with daily 165mg/kg gavage for 12 days, which could promote the healing of acetic acid-type gastric ulcers. Secretion and pepsin activity had no significant effect.
Hypoglycemic effect
Auricularia polysaccharide 33mg/kg or 100mg/kg gavage, can significantly reduce blood glucose levels in alloxan diabetic mice, after oral administration of polysaccharides 4 ~ 7h hypoglycemic effect is most significant; also reduce the water intake of diabetic mice.
Affecting fertility
The intramuscular injection of Auricularia auricula polysaccharide 8.25mg/kg, anti-implantation and anti-pregnancy effect is the most obvious, the role of termination of the mid-term pregnancy is slightly worse, but not for the progestational transport.
Anti-cancer, anti-mutation
The Auricularia auricula hot water extract had an inhibition rate of 42.5% to 70% for the mouse sarcoma S180 in Switzerland and 80% for Ehrlich ascites carcinoma. The Auricularia auricula polysaccharide 200mg/(kg·d), for 10 days, had the effect of increasing the micronucleus rate of bone marrow in mice induced by cyclophosphamide.
Antibacterial effect
The black spiniferin isolated from edible fungus has anti-fungal and other effects.
Remove dark spots
Take 30 grams of black fungus, 20 red dates. Wash the black fungus, jujube to the core, add water, and cook for about half an hour. Every morning and every morning after dinner. Often take it, you can stay in the Freckle, fitness muscle, and for the treatment of facial dark spots, thin shape. The black edible fungus in this recipe is recorded in the Outline of Materia Medica where it can have dark spots on the surface. Black fungus can be emollient, anti-aging skin jujube and Zhongqi, spleen emollient, black fungus will help eliminate dark spots.
Qingwei Polyester radiation protection
The jelly in black fungus can absorb the dust, impurities and radioactive substances that remain in the human digestive system and concentrate it to be excreted from the body, thus playing a role in clearing the stomach, protecting the intestine and preventing radiation.
Gallstones and kidney stones
Because the alkaloids it contains have the property of promoting the secretion of various glands in the digestive tract and urinary tract, plant alkaloids can synergize with these secretions to catalyze the calculus and lubricate the intestinal tract.
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