Drug toxicity
Intraperitoneal injection of Gastrodia extract in mice, the median lethal dose was 51.4-61.4g/kg, rabbits daily injection Tianmao alcohol inhalation 0.25-1g/kg, visible weakness, less appetite, loss of appetite, weight loss, and even death. Such as intraperitoneal injection decoction 12g/kg, there is tired, unresponsive, ataxia, antifeedant, rapid heartbeat. Brain waves appear 1-2 slow waves per second, and 1 case has T wave inversion on the electrocardiogram. Most of the 12 rabbits died within 48 hours of treatment. Vanillol has less side effects, 40 mg/kg intravenously or 1 g/kg intravenously. The general state of the animal and electrocardiogram and electroencephalogram have no special changes. In mice injected intraperitoneally, the median lethal dose of vinciol was 891.3±31.7 mg/kg. Gastrointestinal extracts (each crude drug 7.14g) had a median lethal dose of 0.43ml/10g in male mice x and a female half lethal dose of 0.36ml/10g, which was equivalent to crude drug 0.514g/10g. The gastrodin toxicity was very small. The median lethal dose of intravenous injection was 337mg/kg in dd male mice, half lethal dose> 1000mg/kg in gastric gavage, and the median lethal dose was more than 5000mg/kg.
Animal sub-acute toxicity experiments showed that gastrodin and aglycone had no effect on blood red blood cells and platelets, transaminase, non-protein nitrogen, cholesterol, etc. No degeneration was observed in heart, liver, spleen, lung, kidney, stomach, and intestine slices. Gastrodin and aglycone do not affect the heart rate of rabbits when they are awake, but their heart rate is slightly slower. Rabbits were unresponsive after 30 minutes of intraperitoneal injection of Tianma Shuili 12g/kg, followed by ataxia and antifeedant. After 5 hours, the heart rate increased to more than 300 and died within 48 hours. Tianma injection 1g/kg intravenous injection, produced a significant sedative effect, dorsiflexion and antifeedant, but no changes in ECG and EEG. Vanilloid 40mg/kg intravenously or 1g/kg intragastrically, animals generally in good condition, no change in heart, EEG. The mice were injected intraperitoneally with a lethal dose of 946 mg/kg, and rats were given a median lethal dose of 3000 mg/kg. Gastrodin or p-hydroxybenzaldehyde gavage for 14-60 days for rats and mice had no effect on hemograms, and pathological examinations of important organs such as heart, liver, and kidney showed no abnormal changes. Experiments on the effects of gastrodin derivative acetylated gastrodin on mouse and rat fetuses showed that 373 mg/(kg·day) of acetylated gastrodin was given to the placenta and fetus on the 6th to 15th day after the conception of mice and rats. There was no significant effect on body weight, gender, appearance, visceral and skeletal development. Mice 373-149mg/(kg·day) and rats 32.3-64.5mg/(kg·day) were given intragastric administration on the 6th to 15th days after conception respectively. Compared with the control group, the fetuses were not significantly affected and deformed.
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