Long-acting interferon is expected to "clinically cure" hepatitis B
July 28, 2015 Source: Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];As we all know, China is a big country of hepatitis B. The latest data shows that there are about 30 million patients with chronic hepatitis B. Although everyone is no stranger to hepatitis B, there are widespread cognitive problems in many people who are treated with chronic hepatitis B. The director of the Department of Infectious Diseases, Peking University Third Hospital said: Under the guidance of doctors, patients with hepatitis B can be treated with long-acting interferon, and some patients are expected to achieve no recurrence or even "clinical cure" after stopping the drug.
Many of the questions that many hepatitis B patients ask at the time of the visit are "Is it really bad to get hepatitis B?" In this regard, he said: Hepatitis B treatment is divided into three endpoints. One is an acceptable treatment endpoint. That is to say, the patient's hepatitis B virus has dropped to an undetectable extent, but it cannot be stopped, otherwise it is easy to relapse; the second is a satisfactory treatment end point. That is, a sustained virological response and e antigen seroconversion after drug withdrawal. At this stage, after the antiviral treatment, the patient changed from “big three yang†to “small three yangâ€, which means that the patient can maintain long-lasting effect after stopping the drug; the third is the ideal treatment end point. That is, long-lasting surface antigen clearance after drug withdrawal, with or without surface antigen serological conversion, which is usually referred to as "clinical cure." "Therefore, patients with chronic hepatitis B through scientific and standardized treatment are expected to achieve no recurrence of drug withdrawal, or even 'clinical cure'." Director Yan said.
Does hepatitis B treatment require long-term medication? This is one of the most troublesome problems for patients undergoing nucleoside treatment. "Currently, antiviral drugs for the treatment of chronic hepatitis B include: nucleosides and interferons." Director Yu explained that they can help patients to suppress hepatitis B virus, but because of different mechanisms of action, in achieving satisfactory and ideal treatment. There is a difference in the end point.胥婕Explanation: Nucleoside drugs can inhibit the replication of the virus, although the effect is fast, but it is easy to relapse after stopping the drug, so it is necessary to prepare for long-term treatment. The long-acting interferon can improve the immunity of the body while anti-virus, so that patients can obtain a high and long-lasting e antigen seroconversion, and achieve a "lasting response after stopping the drug" within a limited course of treatment. Studies have shown that after 48 weeks of treatment with long-acting interferon, more than 60% of the dominant patients (high transaminase, low viral load and low surface antigen level) can get "big three yang" to "small three yang", in which patients have 30% received a "clinical cure" during a 3-year follow-up.
胥婕 said: “'Immediate action' is to treat patients with chronic hepatitis B as soon as possible to receive scientific and standardized treatment, reduce the incidence of cirrhosis and liver cancer, and improve the quality of life of patients. Therefore, we recommend that patients with chronic hepatitis B should be in a suitable condition. Try long-acting interferon therapy and give yourself a chance to 'clinically cure'."
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