Vitamin B3 may treat Alzheimer's disease | PNAS
February 12, 2018 Source: Biological Exploration
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Vitamin B3 is one of the 13 essential vitamins in the body. Last year, a 12-year study confirmed that supplementation with microbial B3 during pregnancy could prevent serious birth defects. Now, scientists have discovered that vitamin B3 may also treat Alzheimer's disease, which can slow the damage of brain cognitive and memory functions.
Image source: Network
The application prospect of vitamin B3 in the field of Alzheimer's disease is not the latest discovery. Some research team believes that it can be used as an alternative medicine for Alzheimer's disease. The data suggest that high doses of nicotinamide (also known as vitamin B3) can reverse Alzheimer's disease-related memory impairment.
Now, Vilhelm A. Bohr, head of the Molecular Medicine Laboratory from the National Institute on Aging (NIA), is leading the team to explore a more effective vitamin B3, nicotinamide nucleoside (NR), for brain damage. significance. Related research results were published in the journal PNAS.
Image source: PNAS (doi.org/10.1073/pnas.1718819115)
1. Nicotinamide nucleoside
This vitamin B3 "NR" is an effective precursor of nicotinamide adenine dinucleotide (NAD+) in mitochondria, an important cellular cofactor that improves mitochondrial performance and energy metabolism.
Usually, dementia can damage the DNA repair ability of the brain cells of patients, which leads to mitochondrial dysfunction and eventually causes nerve regeneration disorders. NR is a key substance that maintains mitochondrial health, stem cell self-replication, and neuronal stress.
2 , NR slows nerve damage and improves memory
Vilhelm A. Bohr added NR to the drinking water of Alzheimer's mice and set healthy mice (without adding NR) as a control.
After 3 months, compared with the control group, the loss of Tau protein and DNA in the brain of mice treated with NR was significantly reduced, and the neuroplasticity, learning, and memory function were enhanced. At the same time, the mice in the experimental group were damaged and the number of dead nerves was relatively small. However, it is interesting to note that the levels of β-amyloid in their brains are the same as in the control group.
Mice treated with NR performed better in tests such as maze tasks and object recognition, consistent with positive physiological changes in the brain.
Researchers believe that NR helps to improve the ability of stem cells to self-renew and differentiate. Moreover, NR seems to be able to slow, or even reverse, damage to the hippocampus of the brain.
Next, the research team plans to delve into the mechanisms behind this improvement to advance the application of vitamin B3 in the prevention and treatment of Alzheimer's disease.
References: 1) Vitamin B-3 could be used to treat Alzheimer's
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