BMG microplate reader uses Invitrogen voltage sensing probe technology to easily realize ion channel change detection

BMG microplate reader uses Invitrogen voltage sensing probe technology
Ion channel change detection
 
Ion channels are an important target of drug action because they play a key role in nerve, heart, endocrine and muscle tissue. In drug research, scientists need a highly sensitive method to detect changes in ion channels. Invitrogen's Voltage Sensor Probes (SVP) is a method of detecting changes in cell membrane potential using fluorescence resonance energy transfer (FRET). This method is capable of detecting rapid changes in membrane potential by fluorescence. The key to this test is the need for an instrument that can quickly and continuously detect two different fluorescent signals in FRET. BMG LABTECH's POLARstar Omega and NOVOstar multi-function microplate readers work well with this application.
 
Both POLARstar Omega and NOVOstar can perform FRET and other commonly used detection modes (eg, fluorescence, chemiluminescence, absorbance, time-resolved fluorescence, etc.), as well as dual dual emission detectors. Two fluorescence signals can be detected simultaneously during the Invitrogen SVP experiment, which can detect proportional FRET results and greatly reduce errors due to different cell numbers. Moreover, simultaneous dual emission detection also allows researchers to quickly and more accurately achieve results. In addition, POLARstar Omega and NOVOstar are equipped with two syringes that can be loaded and tested simultaneously on the microplate to ensure that no signals are missed. BMG NOVOstar comes standard with a built-in pipetting system for plate-to-plate pipetting, making it ideal for low to medium throughput (<1000 samples per day). In summary, the functions and design of the BMG POLARstar Omega and NOVOstar multi-function microplate readers are well suited for low-throughput drug screening and ion channel detection.
 
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