Manufacturing points of high-speed mixing granulator:
The manufacture of high-speed mixing granulators (horizontal) should meet the following requirements in accordance with the GMP specifications and the corresponding process requirements for solid preparations.
1. The functional requirements of the high-speed mixing granulator should be 1) dry mixing of the material by the stirring paddle, wet mixing after adding the binder. According to the characteristics of the material and the adhesive, the rotation speed of the stirring paddle ensures that the motion generates eddy current and the material is thoroughly mixed. At the same time, the material of the tumbling knife at the intersection of the granules is fully broken into granules.
2) The rotation speed of the stirring paddle and the granulating knife can make the material produce three-dimensional motion, and the particles will collide, rub and shear, making the friction uniform and meticulous, and the stable spherical particles are shaped after the Zui. The mixing time, the speed of the stirring paddle and the granulating knife, the granulation quality after drying and the uniformity satisfy the requirements of the solid preparation process.
3) The mixing granulation process should be in the closed state, the whole process of mixing granulation (including feeding, mixing, cutting granulation and unloading, etc.) should work under the cleanliness of 100,000 or 300,000 grades, and ensure no foreign matter. fall.
4) The machine can be connected with the boiling drying or lifting feeding or vacuum feeder equipment.
2. Overall structure and manufacturing requirements of high-speed mixing granulator 1) Austenitic stainless steel is used for direct contact with materials, and non-metallic materials should be non-toxic, chemically resistant to chemical changes, and non-corrosive materials that do not absorb chemicals.
2) The granule cylinder is the upper conical cylinder. The bottom of the cylinder should be made by spinning the whole plate. The bottom of the cylinder should be provided with a cooling jacket to ensure that the cylinder does not heat up when it is stirred. The transition of the surface of the cylinder should be a circular arc transition, easy to clean, no dead zone for cleaning. Simultaneously,
The granule cylinders are all welded by argon arc welding, and both internal and external parts need to be polished. Especially, the internal surface polishing surface roughness Ra≤0.8μm ensures that the material will not stick to the wall surface.
3) The feeding port of the granulating cylinder body adopts the quick opening structure, the flange and the barrel body are welded to ensure no dead zone, the cylinder cover is easy to disassemble and open, and the feeding port and the cylinder cover gasket should be sanitary grade silicone rubber, sealed. The pad is easy to change, and the feed inlet and the cap structure should have corresponding airtightness. In addition, the discharge port of the granulating cylinder body adopts an electronically controlled discharge valve, and the valve plate gasket should be sanitary grade silicone rubber, and the entire passage surface of the discharge material is smooth, easy to clean, and has no dead angle of cleaning.
4) The stirring paddle adopts the bottom-rotating agitation. The welding adopts argon arc welding, and both need to be polished. The strength of the connection between the agitating impeller and the bushing should be increased to overcome the instantaneous torque. In addition, the distance between the bottom of the pot and the bottom of the stirring paddle is small (≤1mm) to solve the problem of material accumulation at the bottom of the pot. At the same time, the chopping knife adopts the side-mounted type, the blade is convenient to exchange, and the whole chopping knife assembly has no cleaning dead zone. Among them, the stirring drive shaft and the cylinder seal are easy to seal with air, and can be sealed by water sealing. The sealing of the stirring drive shaft and the cylinder and the sealing of the granulating cutter shaft and the cylinder should be reliably sealed to prevent the powder layer from entering and avoid cross contamination.
5) Austenitic stainless steel polishing tube for gas and water pipelines, using argon arc welding or quick opening connection. When necessary, the gas and water pipelines shall be provided with terminal filters. At the same time, the internal cleaning is convenient. The gas and water pipes can be connected to the shunt ring at the shaft. When the water vapor is converted, the water pressure can be sprayed to various positions of the cylinder to ensure that there is no blind zone for cleaning, and the drain port should be set at a low position.
6) Lubricants cannot be used on the surface of exposed parts, and the lubrication points inside the drive that need to be lubricated shall not cause any pollution to the exposed structure.
7) There must be a mechanical overload protection device. In addition, the compressed air line should be provided with a pressure relief or safety device.
3, electrical and control requirements of high-speed mixing granulator 1) the speed of the stirring paddle and the chopper knife can be at least two-speed motor speed change, the speed range of the stirring paddle is 30-500rpm, the speed of the chopper knife is 300-3000rpm, Frequency control, and can set the display.
2) For the two-speed simple control, the control is equipped with start, emergency, stop switch and fault display, and has current display and second gear motor shift display.
3) When the discharge valve or the drain is closed, the motor that stirs the slurry and the chopper can only run, and vice versa. In addition, the cleaning process can only be entered when the discharge valve is closed.
4) The electrical control should have a self-protection function to prevent damage to the equipment caused by misoperation. These include main motor fault protection and emergency stop protection.
5) For high-end configuration, it should be controlled by PL+ touch color LCD panel. The interface design is divided into manual trial operation interface and normal operation interface, and has a good man-machine dialogue interface. The interface dynamically reflects the main processes (feeding, mixing, cutting granulation, unloading and CIP). The process menu selection and parameters (mixing paddle and granulator speed, mixing and granulating time, CIP time, etc.) can be set to display the set parameters, actual operating parameters, and the cause of the malfunction, as well as the memory function.
4, the basic technology and verification requirements of high-speed mixing granulator 1) running noise ≤ 75dB (A);
2) The speed of the stirring paddle and the granulating knife is in accordance with the process requirements of the corresponding solid preparation;
3) Mixed granulation speed, in line with production requirements;
4) The mixing granulation time is in accordance with the process requirements of the corresponding solid preparation (generally 10-15min/batch);
5) The speed of the stirring paddle and the chopping knife is in accordance with the process requirements of the corresponding solid preparation;
6) Yield >99%;
7) The particle size range of the granulated product is Φ0.17mm-Φ0.83mm (20 mesh-80 mesh) (or according to the process requirements);
8) After drying, the granulation quality should be spherical, uniform in particle size and good in fluidity.
We are ISO Certificated Group Manufactures, three Millions registered Capital, 320 Employees, Professional export experience to more than 70 Countries. such as: Vietnam, Malaysia, The United Arab Emirates, Turkey, South Africa, Nigeria, Brazil, Canada, Peru, USA, UK, Spain, Germany, Poland and so on. Our factory has 3 production work shop. Meanwhile, the factory is equipped with the researching and quality inspection center, with strong technology research and development strength. Now we are standing in front of the industry foundation, we provide quality Veterinary raw materials products and services to target customers around the world.We are professional manufacturer of Pharmaceutical raw materials, ,the best factory price Cosmetic Raw materials, Hot selling Herbal Extracts, Top quality Food Additives and others since the year 2012.
For customer`s needs, OEM service is also acceptable. If you have a good idea in new product production but lack of laboratory device and human resource, we are glad to solve this problem for you. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
The manufacture of high-speed mixing granulators (horizontal) should meet the following requirements in accordance with the GMP specifications and the corresponding process requirements for solid preparations.
1. The functional requirements of the high-speed mixing granulator should be 1) dry mixing of the material by the stirring paddle, wet mixing after adding the binder. According to the characteristics of the material and the adhesive, the rotation speed of the stirring paddle ensures that the motion generates eddy current and the material is thoroughly mixed. At the same time, the material of the tumbling knife at the intersection of the granules is fully broken into granules.
2) The rotation speed of the stirring paddle and the granulating knife can make the material produce three-dimensional motion, and the particles will collide, rub and shear, making the friction uniform and meticulous, and the stable spherical particles are shaped after the Zui. The mixing time, the speed of the stirring paddle and the granulating knife, the granulation quality after drying and the uniformity satisfy the requirements of the solid preparation process.
3) The mixing granulation process should be in the closed state, the whole process of mixing granulation (including feeding, mixing, cutting granulation and unloading, etc.) should work under the cleanliness of 100,000 or 300,000 grades, and ensure no foreign matter. fall.
4) The machine can be connected with the boiling drying or lifting feeding or vacuum feeder equipment.
2. Overall structure and manufacturing requirements of high-speed mixing granulator 1) Austenitic stainless steel is used for direct contact with materials, and non-metallic materials should be non-toxic, chemically resistant to chemical changes, and non-corrosive materials that do not absorb chemicals.
2) The granule cylinder is the upper conical cylinder. The bottom of the cylinder should be made by spinning the whole plate. The bottom of the cylinder should be provided with a cooling jacket to ensure that the cylinder does not heat up when it is stirred. The transition of the surface of the cylinder should be a circular arc transition, easy to clean, no dead zone for cleaning. Simultaneously,
The granule cylinders are all welded by argon arc welding, and both internal and external parts need to be polished. Especially, the internal surface polishing surface roughness Ra≤0.8μm ensures that the material will not stick to the wall surface.
3) The feeding port of the granulating cylinder body adopts the quick opening structure, the flange and the barrel body are welded to ensure no dead zone, the cylinder cover is easy to disassemble and open, and the feeding port and the cylinder cover gasket should be sanitary grade silicone rubber, sealed. The pad is easy to change, and the feed inlet and the cap structure should have corresponding airtightness. In addition, the discharge port of the granulating cylinder body adopts an electronically controlled discharge valve, and the valve plate gasket should be sanitary grade silicone rubber, and the entire passage surface of the discharge material is smooth, easy to clean, and has no dead angle of cleaning.
4) The stirring paddle adopts the bottom-rotating agitation. The welding adopts argon arc welding, and both need to be polished. The strength of the connection between the agitating impeller and the bushing should be increased to overcome the instantaneous torque. In addition, the distance between the bottom of the pot and the bottom of the stirring paddle is small (≤1mm) to solve the problem of material accumulation at the bottom of the pot. At the same time, the chopping knife adopts the side-mounted type, the blade is convenient to exchange, and the whole chopping knife assembly has no cleaning dead zone. Among them, the stirring drive shaft and the cylinder seal are easy to seal with air, and can be sealed by water sealing. The sealing of the stirring drive shaft and the cylinder and the sealing of the granulating cutter shaft and the cylinder should be reliably sealed to prevent the powder layer from entering and avoid cross contamination.
5) Austenitic stainless steel polishing tube for gas and water pipelines, using argon arc welding or quick opening connection. When necessary, the gas and water pipelines shall be provided with terminal filters. At the same time, the internal cleaning is convenient. The gas and water pipes can be connected to the shunt ring at the shaft. When the water vapor is converted, the water pressure can be sprayed to various positions of the cylinder to ensure that there is no blind zone for cleaning, and the drain port should be set at a low position.
6) Lubricants cannot be used on the surface of exposed parts, and the lubrication points inside the drive that need to be lubricated shall not cause any pollution to the exposed structure.
7) There must be a mechanical overload protection device. In addition, the compressed air line should be provided with a pressure relief or safety device.
3, electrical and control requirements of high-speed mixing granulator 1) the speed of the stirring paddle and the chopper knife can be at least two-speed motor speed change, the speed range of the stirring paddle is 30-500rpm, the speed of the chopper knife is 300-3000rpm, Frequency control, and can set the display.
2) For the two-speed simple control, the control is equipped with start, emergency, stop switch and fault display, and has current display and second gear motor shift display.
3) When the discharge valve or the drain is closed, the motor that stirs the slurry and the chopper can only run, and vice versa. In addition, the cleaning process can only be entered when the discharge valve is closed.
4) The electrical control should have a self-protection function to prevent damage to the equipment caused by misoperation. These include main motor fault protection and emergency stop protection.
5) For high-end configuration, it should be controlled by PL+ touch color LCD panel. The interface design is divided into manual trial operation interface and normal operation interface, and has a good man-machine dialogue interface. The interface dynamically reflects the main processes (feeding, mixing, cutting granulation, unloading and CIP). The process menu selection and parameters (mixing paddle and granulator speed, mixing and granulating time, CIP time, etc.) can be set to display the set parameters, actual operating parameters, and the cause of the malfunction, as well as the memory function.
4, the basic technology and verification requirements of high-speed mixing granulator 1) running noise ≤ 75dB (A);
2) The speed of the stirring paddle and the granulating knife is in accordance with the process requirements of the corresponding solid preparation;
3) Mixed granulation speed, in line with production requirements;
4) The mixing granulation time is in accordance with the process requirements of the corresponding solid preparation (generally 10-15min/batch);
5) The speed of the stirring paddle and the chopping knife is in accordance with the process requirements of the corresponding solid preparation;
6) Yield >99%;
7) The particle size range of the granulated product is Φ0.17mm-Φ0.83mm (20 mesh-80 mesh) (or according to the process requirements);
8) After drying, the granulation quality should be spherical, uniform in particle size and good in fluidity.
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We are ISO Certificated Group Manufactures, three Millions registered Capital, 320 Employees, Professional export experience to more than 70 Countries. such as: Vietnam, Malaysia, The United Arab Emirates, Turkey, South Africa, Nigeria, Brazil, Canada, Peru, USA, UK, Spain, Germany, Poland and so on. Our factory has 3 production work shop. Meanwhile, the factory is equipped with the researching and quality inspection center, with strong technology research and development strength. Now we are standing in front of the industry foundation, we provide quality Veterinary raw materials products and services to target customers around the world.We are professional manufacturer of Pharmaceutical raw materials, ,the best factory price Cosmetic Raw materials, Hot selling Herbal Extracts, Top quality Food Additives and others since the year 2012.
For customer`s needs, OEM service is also acceptable. If you have a good idea in new product production but lack of laboratory device and human resource, we are glad to solve this problem for you. Sincerely hope to strengthen exchanges and cooperation with friends from both home and abroad.
Cosmetic raw materials, Magnesium Ascorbyl Phosphate Online,Acetyl Hexapeptide-38 Peptide,Propylparaben Factory Price
Xi'an Henrikang Biotech Co.,Ltd , https://www.xianhenrikangbio.com