Release date: 2016-03-04
Scientists at the University of Bristol will study a potential new approach to treating diabetes, funded by the British Heart Foundation. Dr. Sebastian Oltean was awarded a prize of £268,000 for exploring why diabetes can lead to a “variable splicing†process in the kidneys.
"Alternative splicing" involves the process of translating DNA into a protein that plays an important role in the human body. However, for people with diabetes, diabetes can cause malfunctions in the body, including the kidneys. As a result, abnormal proteins are produced, accelerating the formation of diabetic complications, including proteinuria caused by diabetic nephropathy.
Dr. Oltean's efforts to study the mechanisms by which abnormalities occur during the "alternative splicing" of diabetic patients. He will also try various methods to turn the production of harmful proteins into normal proteins. These studies have succeeded in developing a new approach to treating diabetes.
There should be nearly 3.5 million adult diabetic patients, of which about 500,000 are type 2 diabetes. People with diabetes have a much greater probability of having coronary heart disease than the average person.
Dr. Oltean said that in recent years, people have become more aware of the role of the "alternative splicing" process in various diseases, including diabetes. In this study, the result of our efforts may be a new way to treat diabetes. If we can recognize the mechanism by which diabetes causes "variable splicing" in the kidneys, this may be a new target, and new methods can be developed to organize this process.
Dr. Shannon Amoils, senior consultant at BHF, said that manipulating the “alternative splicing†process in diabetic kidneys eliminates the production of harmful proteins and the production of beneficial proteins is a very challenging task, but it is also an innovative strategy. . Diabetes is a very serious disease that causes an increased risk of heart, circulatory and kidney disease, so it is important that we fund a topic like Dr. Oltean to explore treatments for diabetes. The topics we funded have helped establish many treatments for heart disease. However, we must rely on the generosity of the broad masses of people to fund projects that will have major breakthroughs in the future. For us, it is very important for people to continue to support our work so that we can further improve the treatment and care that people receive.
Source: Noble
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