Precision medicine has stood in the world's "window" and is expected to give birth to the next trillion-level market. Before 2030, China will invest 60 billion yuan in precision medicine . What is precision medicine? How far is it from our lives?
Sponsored by the Qianhai Administration and the Municipal Health Planning Commission, the “2016 Shenzhen Precision Medical Summit†hosted by the Ledong Investment Group and Shenzhen Qianhai International Capital Management College, nearly 500 top experts and scholars in the precision medical field at home and abroad, industry investment elites and the industry. Participants participated in seminars on topics such as “ gene sequencing and big data analysisâ€, “progress in precision medicine in the field of cancerâ€, “integrated medicine and financial investment, and the integration of the Internetâ€.
Deputy Secretary of the Provincial Party Committee, Secretary of the Municipal Party Committee Ma Xingrui, city leaders Guo Yonghang, Tian Fu, Wu Yihuan, etc. attended the summit. Du Peng, the director of the Qianhai Administration, presided over the meeting.
Precision medicine will become the mainstream of medical treatment
"The survival rate of patients with malignant tumors in the United States reaches 85% within five years, and only 25% in China. Many patients in China have already reached the end of cancer, and the operation of precision medicine is imminent." He Jiesheng, former deputy minister of the Ministry of Health, said in his speech. Precision medicine is a tailor-made treatment program that involves individualized treatments in the fields of clinical medicine, pharmacy, nursing, and preventives. There are differences in genes, environments and living habits among individuals. Precision medicine is based on gene big data and is a new method for disease prevention and treatment that takes these factors into consideration.
China has already launched the “Million Genome†program. Last year, the Ministry of Science and Technology proposed that by 2030, China will invest 60 billion yuan in precision medicine. During the two sessions of the National People's Congress this year, the Ministry of Science and Technology announced the “National Guide†for precision medicine.
Some experts believe that precision medicine will usher in the "global multiple play" of China, the United States and Europe in 2016. Under the "three-cycle resonance" of the United States, precision medicine and "cancer landing on the moon" may be overweight. The UK's 100,000 genome plan is welcoming the critical period of rapid advancement from 2016 to 2017. Australia's "100,000 genomes" are also scheduled to start at the end of the year.
The "Million Human Genome Project, and the 'Cancer's Moon' program, aim to make a major breakthrough in the field of cancer, turning cancer into a treatable and curable disease." Former Deputy Director of the State Food and Drug Administration Bian Zhenjia said that in order to achieve this goal, the development of precision medicine needs to be coordinated and coordinated in various aspects and disciplines.
There is still a long way to go from gene to treatment.
It is not a dream to cure cancer accurately. The core technology of precision medicine is gene sequencing. In the opinion of the participants, the gene sequencing industry has gradually begun to be profitable, but there are still a few cases in which cancer is cured by gene therapy. There is still a long way to go before the dream comes true.
"The most expensive disease in the United States is not cancer, but Alzheimer's disease. Precision medicine is of great significance to brain diseases including Alzheimer's disease." Professor Luo Liqun, a professor of biology at Stanford University and a member of the National Academy of Sciences, said in 1991. The first senile dementia caused by genetic diseases was discovered because the genes produced diametrically opposite results by stimulating different amino acid mutations. Up to now, it has been found that less than 10% of Alzheimer's disease originates from single gene changes.
However, Luo Liqun also said that there are still more than 90% of cases, and I still don't know why I am suffering from Alzheimer's disease. From genetic research to final treatment, the road is still very long. "Finding genes is the first step. The more difficult it is to get to the back. The drugs enter the human body in a variety of different reactions. We know very little about this process. But The development of drugs has great potential."
“The key to precision medicine is to effectively combine clinical observations and genomic information.†Wang Yongxiong, a professor at the Department of Statistics at Stanford University and a member of the National Academy of Sciences in the United States, believes that how to establish a large cohort of genes, which genetic variants are important, and how many samples are needed Effective and how to obtain more phenotypic information is an issue that needs to be addressed in genetic research. He suggested establishing a single-gene-themed social network to improve the efficiency of gene observation.
Ma Weihua, chairman of the National Science and Technology Achievements Transformation Guidance Fund and former Governor of China Merchants Bank, said in an interview that genetic sequencing and precision medicine are in the development stage. Chinese capital can be entered in advance, so that technology ownership can be obtained at the beginning. The Chinese market is undertaken to transform it into capital value. Regarding how to promote precision medical projects to Shenzhen, he believes that it is necessary to further open up, make foreign research results easy to enter, and quickly industrialize, while vigorously absorbing venture capital.
Shenzhen has the conditions to become a pioneer in precision medicine
A number of participants said in an interview that Shenzhen's industrial base and environment are the "fertile soil" for the development of precision medicine, and it is a prerequisite for the development of precision medicine. Shenzhen is an important electronic information industry base and the first batch of national bio-industry bases in the world. The cloud computing, Internet of Things and supercomputing capabilities are leading the country, and the life and health advantage industry leads the country.
The reporter learned that from the perspective of segmentation, Shenzhen's next-generation sequencing capability and ultra-large-scale bioinformatics computing and analysis capabilities rank first in the world, with Asia's largest comprehensive stem cell bank and the world's first through the American Association of Blood Banks (AABB). Certified integrated stem cell bank group; complete system of independent innovation platform, and 18 national-level innovation carriers related to life and health fields such as national gene bank.
It is worth mentioning that Huada Health has established a precision medical alliance to carry out non-invasive prenatal genetic testing demonstration applications and disease screening services to achieve accurate prevention and control of birth defects. The Second People's Hospital of the city has launched a “precise treatment planâ€. "The use of CAR-T technology in the treatment of relapsed, refractory acute lymphoblastic leukemia and lymphoma was successful.
It is reported that at present, Shenzhen is committed to building an international medical center and has issued the "Implementation Opinions on Deepening the Reform of the Medical and Health System and Building a Healthy and Strong City". By 2018, Shenzhen will build 40 high-level medical technology innovation platforms to promote breakthroughs in precision medical technology and promote accurate prevention and treatment of malignant tumors, major chronic diseases, birth defects, and rare diseases.
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