Recently, our company developed bone growth hormone peptide, also known as osteogenic growth peptide.
Osteogenic growth peptide (OGP) is a newly discovered polypeptide growth factor that promotes osteogenesis and stimulates hematopoiesis.
Osteogenic growth peptide can increase the expression of type I collagen mRNA, increase alkaline phosphatase activity, collagen synthesis and calcium salt deposition. Therefore, osteogenic growth peptides regulate the function of osteoblast-like cells, allowing cells to differentiate and promote osteogenesis. The osteogenic growth peptide is a small peptide chain consisting of 14 amino acids.
Osteogenic growth peptide can be used for the treatment of bone grafts, fractures, fractures, osteoporosis, etc., and can also be applied to orthopedics and oral surgery. It is an osteogenic drug with broad development prospects.
Osteogenic growth peptide is a peptide growth factor discovered in the 1990s that promotes bone formation and stimulates hematopoiesis. Molecular biology and biochemical studies have found that osteogenic growth peptide can up-regulate osteoblast-like cells type I collagen mRNA, bone calcium mRNA, Alkaline phosphatase mRNA expression. Osteogenic growth peptide can also significantly increase the collagen, osteocalcin, calcium content and alkaline phosphatase activity (P<0.05-0.001). Morphological observation of osteogenic growth peptide can stimulate the formation of trabecular structures and calcified nodules. .
Osteogenic growth peptide can increase the synthesis of collagen and osteocalcin in osteoblast-like cells, and increase the alkaline phosphatase activity of cells, which can increase the translation level of collagen, osteocalcin and alkaline phosphatase. Osteocalcin and alkaline phosphatase are indicators of differentiation of osteoblasts.
Type I collagen constitutes the protein framework of bone tissue, and the synthesis and decomposition of type I collagen are also direct and specific indicators of bone tissue synthesis and absorption.
Since the osteogenic growth peptide regulates osteoblast-like cell function, the cells differentiate, increase collagen synthesis and secretion, and accelerate mineralization. Therefore, the osteogenic growth peptide has an osteogenic effect.
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