Chinese scientists discover new anti-hepatitis B virus genes
June 12, 2016 Source: China News Network
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];The team of researchers from the Institute of Radiation and Radiation Medicine of the PLA Academy of Military Medical Sciences led a number of research institutions in the United Nations. For the first time, from the perspectives of genetics, virology, function and molecular mechanism, an "integration factor complex" gene INTS10 was first discovered. Activates the innate immune function of the human body and plays a role in inhibiting the replication of hepatitis B virus.
This research reveals that the "integration factor complex" has a new role in inhibiting the infection of pathogenic microorganisms that has never been discovered before, opening a new direction for its research. At the same time, it helps to understand the molecular mechanism of chronic hepatitis B virus infection, and provides a theoretical basis and a new candidate biological target for effective prevention and treatment. The research results were published in the journal Nature Communication.
At present, there are about 120 million chronic carriers of hepatitis B virus in China. Prevention and treatment of chronic hepatitis B involves national economy and people's livelihood. In order to discover susceptibility genes or resistance genes associated with chronic hepatitis B virus infection, Zhou Gangqiao's research team led researchers from Guangxi Medical University, Nanjing Medical University and Sun Yat-sen University to collect more than 10,000 pieces of whole-genome data. A total of 1251 chronic hepatitis B virus infection patients and 1057 control individuals who had naturally cleared hepatitis B virus infection were screened, and the genetic differences between the two groups were systematically compared. Subsequently, in a total of 3,905 infected individuals and 3,356 control individuals from four other regions in the country, these genetic differences were extensively verified, and a new HBV infection was found at chromosome 8p21.3. The genetic region. Further functional studies have shown that the INTS10 gene in this region can activate the key molecule IRF3 in the intracellular RIG-I-like receptor pathway, and significantly promote the expression of type III interferon, and finally play a role in inhibiting hepatitis B virus replication.
The "integration factor complex" is a multifunctional protein complex composed of at least 12 members that mediates the processing of ribonucleic acid and plays an important role in genomic damage response and tumor development. However, in the past, no members of the integrated factor complex have been found to play a role in the pathogenesis of pathogenic microorganisms. Therefore, this study first discovered that the complex has a previously unknown new function, which is the study of the integrated factor complex and the pathogen. The study of microbial infection mechanisms provides a new perspective. It is well known that interferon-induced immune responses are the key to resisting hepatitis B virus infection, but previous studies have focused on type I and type II interferons secreted by immune cells. The study found that hepatocytes themselves secrete type III interferons and thus inhibit the replication of hepatitis B virus, thus providing a new theoretical basis for the treatment of chronic hepatitis B with type III interferon.
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