A team from Singapore recently discovered a class of small RNA molecules called oncomiRs that are involved in the energy supply of lung cancer. The research was published in the journal Nature Communications. This study provides new insights into scientists' understanding of lung cancer resistance and opens up new avenues for improving treatment outcomes and monitoring treatment.
Tumor stem cells located inside the tumor are tolerant to traditional treatment. Cancer stem cells are the main culprit in the recurrence of lung cancer patients, and oncomiRs is the main driver of cancer stem cells. If there are treatments that can eliminate oncomiRs in cancer stem cells, then it will be greatly Improve the possibility of cancer stem cells.
Researchers have invented a new treatment called locked nucleic acid (LNA), which is specifically targeted at oncomiRs in cancer stem cells. In the mouse model, the researchers have successfully applied this treatment to remove lung cancer from mice, and the research team is currently working on making this treatment a drug that can be applied to humans.
In addition, the researchers also found that oncomiRs can be detected in the patient's blood, and this method of detection is less invasive and less time-consuming than traditional tissue biopsy. And the level of oncomiRs can predict the patient's response to treatment. Tracking the level of oncomiRs in the blood of patients receiving standard treatment in real time can help the researcher understand the patient's response to treatment and predict whether the patient has relapsed or metastasized.
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