Recently, a team of professors from the University of North Carolina at Chapel Hill and North Carolina State University, Professor Gu Wei and Professor John Buse developed a new technology. It can make red blood cells act as smart couriers of insulin, and automatically control the blood sugar level of type 1 diabetic mice according to blood sugar concentration. This achievement was published online in the latest issue of Advanced Materials, the leading academic journal in materials science.
â–² Professor Gu Yu (Source: UNC Health Care News)
Professor Gu Yu studied under the famous chemical engineering scientist and biomedical entrepreneur Robert Langer, who together invented a micro-nano particle for subcutaneous injection containing insulin. The size of this granule is only one thousandth of a grain of sand, but it can effectively regulate the blood sugar of diabetic mice. In North Carolina, his team is dedicated to researching the “smart delivery methods†of drugs and has achieved a number of results with transformative potential. In 2015, Professor Gu Yu and the team developed a “smart insulin patch†containing a series of vesicles containing insulin and glucose oxidase. When blood sugar rises, glucose penetrates into these vesicles and is oxidized by glucose oxidase, producing an environment that is deficient in oxygen or rich in hydrogen peroxide. This promotes rupture of the vesicles and rapidly releases the insulin, which acts as an "automatic blood sugar lowering".
In the mouse trial, the patch was a success – only half an hour after the skin was applied, it effectively reduced blood sugar for up to 9 hours. This "smart micro-needle" was selected as one of the top ten scientific pictures of Science in the year. Professor Gu Yu was also selected by the MIT Science and Technology Review as 35 innovators under the age of 35. At present, his team is actively carrying out pre-clinical large animal experiments, and the goal is to enter clinical trials as soon as possible.
â–²Intelligent insulin patch (middle) was selected as one of the top ten scientific pictures of Science magazine in 2015 (Source: Science)
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