[Inventory] 2015 Top Ten Medical Black Technology

The year 2015 has ended. Last year, medical technology developed so fast that sometimes it would not be able to keep up with the times. It is very likely that there will be new scientific and technological achievements tomorrow. But we still can't wait to make an inventory for everyone. These black technology, which occurred in 2015, may have appeared in 2014, but this year it really started to be known and began to benefit the people; some may still be in laboratory research, but they have very large market value; Some may have been commercialized, but they reflect a lot of innovation. Although it may not be comprehensive, but in any case, these are a trend that represents medical technology, so let's get started!

1. Microfluidic biodiagnostic chip that can diagnose a variety of diseases

IBM researchers have developed a portable diagnostic chip that can quantitatively detect multiple diseases. Thanks to the powerful research by IBM researchers LucGervais and Emmanuel Delamarche, the use of capillary tension to drive microfluidics can dramatically change the current state of point care diagnostics.

At the IBM Zurich laboratory, scientists have combined microfluidic components with analyte molecules, detection antibodies, capture antibodies and other reagents to creatively propose a one-step immunoassay. Only 5 microliters of human serum samples are required to complete the sandwich immunoassay and the results are read using a fluorescence microscope. The microfluidic functional element consists of a reaction chamber sealed with a PDMS substrate, a sample collector, a time delay valve, a deposition zone for detection of antibodies, a capillary pump, and a fluid inlet and outlet.

A well-designed microfluidic channel is placed on the chip used in the one-step immunoassay, allowing us to precisely control the volume and flow rate of the liquid to be analyzed on the chip. The deposition zone of the detection antibody and the capture antibody can be precisely defined, so that a small number of samples to be tested and a small detection area can be used to complete the detection task. And because the detection area is small, multiple proteins can be analyzed simultaneously on a single chip.

The chip prototype used in this study is capable of detecting the cardiac marker C-reactive protein (CRP), and the chip can also provide quantitative detection for cancer, allergies, viruses, bacteria, and diseases with any known protein marker.

In the future, the further development of a multifunctional chip that relies entirely on capillary tension demonstrates the potential of PDMS as a diagnostic test and a biological base for a lab.

Coris BioConcept and IBM are working together to bring a one-step diagnostic chip to market. Researchers hope to eventually make the device from plastic components and promote it in hospitals. In addition, IBM plans to leverage its strengths in semiconductor technology and manufacturing experience to actively develop point-of-care products in collaboration with other biologists, including Neuro-Zone, which develops devices for detecting brain cells in the treatment of neurological diseases.

2. 3D printed pills for treating epilepsy

A new generation of magical technology "3D printing" can print and eat, and still drugs! A considerable number of researchers are working on the development of this technology. For example, the International Journal of Pharmaceuticals reported that researchers at the University College of London have successfully tested 3D printed tablet technology. At this point, the US company Aprecia is ahead of the scene, they announced that the US Food and Drug Administration (FDA) has approved its "the world's first" 3D printing drug Spritam (Lesilacetam) instant tablets, which The drug is used to treat epilepsy.

I have to say that this is a milestone in the entire 3D printing field. Because it means that millions of identical products can be manufactured at the same time.

In addition to convenience and personalization, the unique advantages of 3D printing technology can not be ignored, that is, it is more controllable in structure, which is the ability that traditional manufacturing methods can't match. The advantage of using 3D printing drugs is that it contains a lot of holes, which only need a little water to dissolve in the mouth, which is very easy for patients with difficulty swallowing (such as patients with seizures). Drugs with holes can also be made by conventional methods, but are more difficult and more expensive.

Imagine the future, printing drugs may be able to meet more customized medical needs. Other researchers believe that 3D printing drugs may provide cheaper drug production methods for developing countries.

RT-PCR Test Reagent Kit Of COVID-19(ORF1ab, N)

The RT-PCR Test Reagent Kit Of COVID-19(ORF1ab, N) is a real-time RT-PCR test intended for the qualitative detection of nucleic acid from the SARS-CoV-2 in upper and lower respiratory specimens (such as anterior nasal swabs, mid-turbinate nasal swabs, nasopharyngeal swabs, oropharyngeal swabs, sputum, lower respiratory tract aspirates, bronchoalveolar lavage, and nasopharyngeal wash/aspirate or nasal aspirate) from individuals suspected of COVID-19 by their healthcare provider.

Results are for the identification of SARS-CoV-2 RNA.The SARS-CoV-2 RNA is generally detectable in upper and lower respiratory specimens during the acute phase of infection.

Positive results are indicative of the presence of SARS-CoV-2 RNA; clinical correlation with patient history and other diagnostic information is necessary to determine patient infective status. The agent detected may not be the definite cause of disease. Positive results do not rule out bacterial co-infection with other viruses.

Negative results do not preclude SARS-CoV-2 infection and should not be used as the sole basis for patient management decisions. Negative results must be combined with clinical observations, patient history, and epidemiological information. The COVID-19 RT-PCR Detection Kit is intended for use by qualified trained clinical laboratory personnel specifically instructed and trained in the techniques of real-time PCR and in vitro diagnostic procedures.

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